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betacellulin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

685

PubChem

685

Alliance of Genome Resources

HGNC:1121

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Mitogen
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P35070
A0A0S2Z437
A0A0S2Z3I5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
epidermal growth factor receptor signaling pathway	IBA
cell population proliferation	IEA
positive regulation of cell population proliferation	IBA
positive regulation of urine volume	IEA
ERBB2-EGFR signaling pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2-EGFR signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-EGFR signaling pathway

ERBB4 signaling pathway [inference]

ERBB4-ERBB4 signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process

cell population proliferation

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

regulation of urine volume [inference]

positive regulation of urine volume

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

positive regulation of cell differentiation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell division

positive regulation of developmental process [inference]

positive regulation of cell differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2-EGFR signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-EGFR signaling pathway

ERBB4 signaling pathway [inference]

ERBB4-ERBB4 signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

regulation of fibroblast proliferation [inference]

positive regulation of fibroblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of fibroblast proliferation

positive regulation of cell differentiation

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell division

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of epithelial cell apoptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell division [inference]

positive regulation of cell division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of urine volume [inference]

positive regulation of urine volume

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	12399441 9168114
extracellular space	IBA
plasma membrane	IEA
clathrin-coated endocytic vesicle membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
epidermal growth factor receptor binding	IBA
protein binding	IPI	19740107 25416956 25910212 26871637 32296183
growth factor activity	IBA
transmembrane receptor protein tyrosine kinase activator activity	IDA	12399441 9168114
receptor ligand activity	IDA	12399441 9168114

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity

growth factor activity

growth factor receptor binding [inference]

epidermal growth factor receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pro-neuregulin-3, membrane-bound isoform-like

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
epidermal growth factor receptor signaling pathway
growth factor activity
positive regulation of cell population proliferation
positive regulation of mitotic nuclear division

Displaying 1 entry
InterPro
EGF-like domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 33 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	685	Xenbase:XB-GENE-995923
Mus musculus	12223	Xenbase:XB-GENE-995923	MOUSE45586
Rattus norvegicus	64022		RATNO09143
Bos taurus	280737		BOVIN31673
Pan troglodytes	461250		PANTR33741
Canis lupus familiaris	482682		CANLF04388
Macaca mulatta	702178		MACMU37744
Oryctolagus cuniculus	100343154		RABIT05318
Callithrix jacchus	100387579		CALJA27670
Ailuropoda melanoleuca	100464737		AILME12847