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synapsin I

Summary

Gene Symbol

SYN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6853

PubChem

6853

Alliance of Genome Resources

HGNC:11494

JoGo

SYN1

TogoVar

SYN1

Annotation

Keyword

Actin-binding
Alternative splicing
Cell projection
Cytoplasmic vesicle
Disease variant
Epilepsy
Glycoprotein
Golgi apparatus
Intellectual disability
Methylation
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Synapse

Proteins

Displaying 1 entry
UniProt	Protein Name
P17600	Brain protein 4.1 Synapsin I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chemical synaptic transmission	TAS	2110562
neurotransmitter secretion	IEA
regulation of neurotransmitter secretion	TAS	21563316
neuron development	IEA
synapse organization	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

vesicle-mediated transport [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle cycle

cellular developmental process [inference]

cell development [inference]

neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

neuron development

cellular developmental process [inference]

cell development [inference]

neuron development

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

vesicle-mediated transport [inference]

vesicle-mediated transport in synapse [inference]

synaptic vesicle cycle

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

organelle localization [inference]

vesicle localization [inference]

synaptic vesicle localization [inference]

synaptic vesicle clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic vesicle exocytosis

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle cycle

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic vesicle cycle

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion

regulation of synaptic vesicle exocytosis

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
Schaffer collateral - CA1 synapse	IEA
presynapse	IDA	21441247
extrinsic component of synaptic vesicle membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

postsynaptic specialization [inference]

postsynaptic density

synaptonemal structure [inference]

synaptonemal complex

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	23406870
ATP binding	TAS	15217342
protein kinase binding	ISS
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

cytoskeletal anchor activity [inference]

cytoskeletal protein-membrane anchor activity

protein-membrane adaptor activity [inference]

cytoskeletal protein-membrane anchor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0112029	non-syndromic X-linked intellectual disability 50	Alliance of Genome Resources
DOID:0112122	X-linked epilepsy with variable learning disabilities and behavior disorders	Alliance of Genome Resources