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tachykinin receptor 2

Summary

Gene Symbol

TACR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6865

PubChem

6865

Alliance of Genome Resources

HGNC:11527

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P21452	NK-2 receptor Neurokinin A receptor Tachykinin receptor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
muscle contraction	TAS	2173708
tachykinin receptor signaling pathway	TAS	8307161
positive regulation of acetylcholine secretion, neurotransmission	IEA
intestine smooth muscle contraction	IEA
negative regulation of luteinizing hormone secretion	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

tachykinin receptor signaling pathway

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

prolactin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

smooth muscle contraction [inference]

phasic smooth muscle contraction [inference]

intestine smooth muscle contraction

gastro-intestinal system smooth muscle contraction [inference]

intestine smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

operant conditioning

behavior [inference]

learning or memory [inference]

learning [inference]

operant conditioning

response to stimulus [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

secretion by cell [inference]

protein secretion [inference]

prolactin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

prolactin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

prolactin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

prolactin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

positive regulation of ion transport

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of transport [inference]

positive regulation of ion transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of amine transport [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

regulation of cell motility [inference]

regulation of cilium-dependent cell motility [inference]

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cellular process [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

positive regulation of transport [inference]

positive regulation of ion transport

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of amine transport [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of uterine smooth muscle contraction

positive regulation of reproductive process [inference]

positive regulation of flagellated sperm motility

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of multicellular organismal process [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

tachykinin receptor signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic [inference]

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of cilium movement [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cellular process [inference]

positive regulation of cilium movement [inference]

positive regulation of flagellated sperm motility

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of synaptic transmission, cholinergic [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of neurotransmitter secretion [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of acetylcholine secretion, neurotransmission [inference]

positive regulation of acetylcholine secretion, neurotransmission

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

positive regulation of secretion by cell [inference]

positive regulation of neurotransmitter secretion [inference]

positive regulation of acetylcholine secretion, neurotransmission

regulation of cell motility [inference]

regulation of cilium-dependent cell motility [inference]

regulation of cilium movement involved in cell motility [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

positive regulation of cell motility [inference]

positive regulation of cilium-dependent cell motility [inference]

positive regulation of flagellated sperm motility

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of uterine smooth muscle contraction

regulation of uterine smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of uterine smooth muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of uterine smooth muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of reproductive process [inference]

regulation of flagellated sperm motility [inference]

positive regulation of flagellated sperm motility

positive regulation of reproductive process [inference]

positive regulation of flagellated sperm motility

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

prolactin secretion

regulation of hormone secretion [inference]

regulation of gonadotropin secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of luteinizing hormone secretion [inference]

negative regulation of luteinizing hormone secretion

negative regulation of hormone secretion [inference]

negative regulation of gonadotropin secretion [inference]

negative regulation of luteinizing hormone secretion

regulation of vascular permeability [inference]

positive regulation of vascular permeability

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
sperm midpiece	IDA	17437961
sperm midpiece	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium [inference]

sperm flagellum

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tachykinin receptor activity	TAS	8307161
protein binding	IPI	12716968 23597562
substance K receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

tachykinin receptor activity

substance K receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled peptide receptor activity [inference]

neuropeptide receptor activity [inference]

tachykinin receptor activity

substance K receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
positive regulation of flagellated sperm motility
tachykinin receptor activity
tachykinin receptor signaling pathway

Displaying **all 3** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Neurokinin receptor

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Macaca fascicularis	102145240	MACFA42744
Capra hircus	102190490	CAPHI18700
Myotis lucifugus	102440739	MYOLU12422
Chlorocebus sabaeus	103216075	CHLSB17853
Ursus maritimus	103668005	URSMA03563
Nannospalax galili	103729732	NANGA21612
Rhinopithecus roxellana	104661964	RHIRO20972
Pteropus vampyrus	105300109	PTEVA13368
Macaca nemestrina	105466096	MACNE09946
Mandrillus leucophaeus	105547437	MANLE07060

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Acknowledgements