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propionyl-CoA carboxylase subunit alpha

Summary

Gene Symbol

Pcca

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

687008

PubChem

687008

Alliance of Genome Resources

RGD:3264

Annotation

Keyword

ATP-binding
Acetylation
Biotin
Direct protein sequencing
Ligase
Lipid degradation
Magnesium
Manganese
Metal-binding
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P14882	Propanoyl-CoA:carbon dioxide ligase subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carboxylic acid metabolic process	IEA
fatty acid catabolic process	TAS	2745462
lipid catabolic process	IEA
amino acid catabolic process	TAS	2745462

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

amino acid metabolic process [inference]

amino acid catabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process

lipid metabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

amino acid metabolic process [inference]

amino acid catabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

amino acid metabolic process [inference]

amino acid catabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

lipid metabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process

amino acid metabolic process [inference]

amino acid catabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process

cellular lipid catabolic process [inference]

fatty acid catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
catalytic complex	IEA ISO
mitochondrion	IBA ISO
mitochondrial matrix	IEA ISO ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
enzyme binding	IEA ISO
metal ion binding	IEA
propionyl-CoA carboxylase activity	IBA IEA ISO ISS TAS	2745462
ATP binding	IEA
ligase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity

ligase activity, forming carbon-carbon bonds [inference]

CoA carboxylase activity [inference]

propionyl-CoA carboxylase activity

binding [inference]

protein binding [inference]

enzyme binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

propionyl-CoA carboxylase alpha chain, mitochondrial

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 7** entries
Gene Ontology
ATP binding
ligase activity
metal ion binding
methylcrotonoyl-CoA carboxylase activity
nucleotide binding
propionyl-CoA carboxylase activity
urea carboxylase activity

Displaying entries **1 - 10** of 12 in total

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2

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InterPro
ATP-grasp fold, subdomain 1
ATP-grasp fold
Biotin carboxylase, C-terminal
Biotin carboxylase-like, N-terminal domain
Biotin carboxylation domain
Biotin-binding site
Biotin/lipoyl attachment
Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Pre-ATP-grasp domain superfamily
Propionyl-coenzyme A carboxylase, BT domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:14701	propionic acidemia	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of **108** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pelodiscus sinensis	102453505			PELSI07448
Peromyscus maniculatus bairdii	102907027	230844_0:003172
Chlorocebus sabaeus	103214726			CHLSB13812
Carlito syrichta	103266293			CARSF13041
Ursus maritimus	103657568			URSMA06850
Nannospalax galili	103733836	1026970_0:0015b7		NANGA21961
Serinus canaria	103812620			SERCA01908
Rhinopithecus roxellana	104666437			RHIRO12817
Fukomys damarensis	104848566	885580_0:00088e
Pteropus vampyrus	105294140			PTEVA12616

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024