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MIRAGE
mitogen-activated protein kinase kinase kinase 7
Summary
- Gene Symbol
-
- MAP3K7
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Alternative splicing
- Apoptosis
- Cell membrane
- Cytoplasm
- Disease variant
- Host-virus interaction
- Isopeptide bond
- Magnesium
- Metal-binding
- Phosphoprotein
- Reference proteome
- Serine/threonine-protein kinase
- Stress response
- Transcription regulation
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| O43318 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| MAPK cascade | ||
| stimulatory C-type lectin receptor signaling pathway | ||
| positive regulation of T cell cytokine production | ||
| cytoplasmic pattern recognition receptor signaling pathway | ||
| MyD88-dependent toll-like receptor signaling pathway |
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of adaptive immune response [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of adaptive immune response [inference]
regulation of innate immune response [inference]
positive regulation of immune response [inference]
regulation of response to stress [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
positive regulation of cellular process [inference]
regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| magnesium ion binding | ||
| transcription coactivator binding | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity | ||
| protein serine/threonine kinase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- mitogen-activated protein kinase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| JNK cascade |
| immune response |
| kinase activity |
| magnesium ion binding |
| nucleotide binding |
| phosphorylation |
| positive regulation of canonical NF-kappaB signal transduction |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111785 | frontometaphyseal dysplasia | |
| DOID:0111787 | frontometaphyseal dysplasia 2 | |
| DOID:10283 | prostate cancer |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 6885 | Xenbase:XB-GENE-481530 | ||
| 26409 | Xenbase:XB-GENE-481530 | MOUSE42368 | |
| 313121 | Xenbase:XB-GENE-481530 | RATNO32398 | |
| 462888 | PANTR38711 | ||
| 529146 | BOVIN35676 | ||
| 553788 | DANRE18992 | ||
| 703101 | MACMU33403 | ||
| 100019975 | MONDO12228 | ||
| 100065841 | HORSE01106 | ||
| 100135663 | PIGXX13693 |
