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transaldolase 1

Summary

Gene Symbol

TALDO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6888

HGNC

11559

KEGG Gene ID

hsa:6888

PubChem

6888

Alliance of Genome Resources

HGNC:11559

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Cytoplasm
Disease variant
Nucleus
Pentose shunt
Phosphoprotein
Reference proteome
Schiff base
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A140VK56
P37837

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
fructose 6-phosphate metabolic process	IEA
pentose-phosphate shunt, non-oxidative branch	IMP	18498245
pentose-phosphate shunt, non-oxidative branch	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

generation of precursor metabolites and energy [inference]

pentose-phosphate shunt, non-oxidative branch

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

carbohydrate derivative metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

generation of precursor metabolites and energy [inference]

pentose-phosphate shunt, non-oxidative branch

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

organophosphate metabolic process [inference]

fructose 6-phosphate metabolic process

glyceraldehyde-3-phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

ribose phosphate metabolic process [inference]

pentose-phosphate shunt, non-oxidative branch

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleus	HDA	21630459
cytoplasm	TAS	16130169
cytosol	TAS
cytosol	IDA	18498245

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
transaldolase activity	IDA	18687684
transaldolase activity	IMP	18498245
transaldolase activity	IBA
protein binding	IPI	21044950 25854864 32814053
monosaccharide binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transketolase or transaldolase activity [inference]

transaldolase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding

small molecule binding [inference]

monosaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transaldolase

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
pentose-phosphate shunt, non-oxidative branch
pentose-phosphate shunt
transaldolase activity
transferase activity

Displaying **all 4** entries
InterPro
Aldolase-type TIM barrel
Transaldolase type 1
Transaldolase, active site
Transaldolase/Fructose-6-phosphate aldolase

KEGG BRITE Database

Orthology

K00616

Name

transaldolase [EC:2.2.1.2]

References

Rhea

RHEA:17053

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

D-erythrose 4-phosphate + β-D-fructose 6-phosphate

Enzyme

2.2.1.2

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2978	carbohydrate metabolic disorder	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 45 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000056	Abnormal clitoris morphology
HP:0000077	Abnormality of the kidney
HP:0000154	Wide mouth
HP:0000233	Thin vermilion border
HP:0000260	Wide anterior fontanel
HP:0000322	Short philtrum
HP:0000325	Triangular face
HP:0000369	Low-set ears
HP:0000470	Short neck

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:606003	transaldolase deficiency
ORPHA:101028	transaldolase deficiency

PubChem Disease

MedGen Diseases

Deficiency of transaldolase

OMIM Phenotypes

TRANSALDOLASE DEFICIENCY; TALDOD

KEGG Diseases

Transaldolase deficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6888	Xenbase:XB-GENE-1005380
Mus musculus	21351	Xenbase:XB-GENE-1005380	MOUSE57109
Xenopus tropicalis	37804	Xenbase:XB-GENE-1005380
Rattus norvegicus	83688	Xenbase:XB-GENE-1005380	RATNO20067
Pan troglodytes	450933		PANTR01935
Bos taurus	513453		BOVIN23763
Xenopus tropicalis	851068	Xenbase:XB-GENE-1005380
Xenopus tropicalis	852934	Xenbase:XB-GENE-1005380
Ornithorhynchus anatinus	100083954		ORNAN18094
Ciona intestinalis	100176649		CIOIN04284

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UniCarb-DR

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements