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TAP binding protein

Summary

Gene Symbol

TAPBP

Organism

Homo sapiens (human)

External Links

NCBI Gene

6892

PubChem

6892

Alliance of Genome Resources

HGNC:11566

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Immunoglobulin domain
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0A0MT98	TAP-binding protein
A0A0A0MSV9	TAP-binding protein
A0A024RCT1	TAP-binding protein
O15533	NGS-17 TAP-associated protein TAP-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
MHC class Ib protein complex assembly	IMP	12582157
peptide antigen assembly with MHC class I protein complex	IDA	10636848 17603487
peptide antigen assembly with MHC class I protein complex	IBA
protein folding	IEA
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	NAS	11884415

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide stabilization [inference]

peptide antigen stabilization

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide stabilization [inference]

peptide antigen stabilization

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide stabilization [inference]

peptide antigen stabilization

cellular process [inference]

protein folding

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

MHC protein complex assembly [inference]

MHC class Ib protein complex assembly

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

protein-containing complex organization [inference]

protein-containing complex assembly

MHC protein complex assembly [inference]

MHC class Ib protein complex assembly

peptide antigen assembly with MHC protein complex [inference]

peptide antigen assembly with MHC class I protein complex

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of biological quality [inference]

regulation of protein complex stability

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GO Term	Evidence Code	PMID
Golgi membrane	IDA	11884415
endoplasmic reticulum	IC	17947644
endoplasmic reticulum membrane	IDA	11884415
phagocytic vesicle membrane	TAS
endoplasmic reticulum-Golgi intermediate compartment membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

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GO Term	Evidence Code	PMID
protein binding	IPI	12213826 15793001 17055437 18802093 19201886 22810586
MHC class I protein complex binding	IBA
MHC class I protein binding	TAS	12788224
peptide antigen binding	TAS	12788224
protein folding chaperone	IDA	36104323

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

MHC class I protein binding

TAP binding [inference]

unfolded protein binding

amide binding [inference]

peptide binding [inference]

peptide antigen binding

protein-containing complex binding [inference]

MHC protein complex binding [inference]

MHC class I protein complex binding

TAP complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tapasin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
MHC class I protein complex binding
TAP complex binding
peptide antigen assembly with MHC class I protein complex

Displaying **all 4** entries
InterPro
Immunoglobulin C1-set
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:627	severe combined immunodeficiency	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 66 in total

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Species	Gene ID	Orthologous MAtrix
Salmo salar	100136493	SALSA97348
Ovis aries	100170652	SHEEP10156
Oryctolagus cuniculus	100354694	RABIT02321
Callithrix jacchus	100409944	CALJA30725
Pongo abelii	100431428	PONAB31402
Ailuropoda melanoleuca	100484836	AILME17768
Oryzias latipes	100529188	ORYLA01910
Loxodonta africana	100670659	LOXAF03057
Oreochromis niloticus	100701247	ORENI41402
Cricetulus griseus	100775092	CRIGR21097

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

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Acknowledgements