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ryanodine receptor 2

Summary

Gene Symbol

Ryr2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

689560

PubChem

689560

Alliance of Genome Resources

RGD:620314

Annotation

Keyword

3D-structure
Alternative splicing
Calcium channel
Calmodulin-binding
Developmental protein
Ligand-gated ion channel
Phosphoprotein
Receptor
Reference proteome
Repeat
Sarcoplasmic reticulum
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
B0LPN4	Cardiac muscle ryanodine receptor Cardiac muscle ryanodine receptor-calcium release channel Type 2 ryanodine receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 59 in total

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GO Term	Evidence Code	PMID
response to hypoxia	ISO
response to hypoxia	IEP	22962011
regulation of heart rate	ISO
embryonic heart tube morphogenesis	ISS
embryonic heart tube morphogenesis	ISO

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cardiac conduction [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

cell communication involved in cardiac conduction [inference]

cell-cell signaling involved in cardiac conduction [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

Purkinje myocyte to ventricular cardiac muscle cell communication [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

type B pancreatic cell apoptotic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction

cardiac muscle contraction

muscle hypertrophy [inference]

striated muscle hypertrophy [inference]

cardiac muscle hypertrophy

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis [inference]

left ventricular cardiac muscle tissue morphogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to epinephrine [inference]

cellular response to epinephrine stimulus

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to epinephrine [inference]

cellular response to epinephrine stimulus

response to calcium ion

detection of calcium ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to magnesium ion

response to calcium ion

detection of calcium ion

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to epinephrine [inference]

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to oxygen-containing compound [inference]

response to calcium ion

detection of calcium ion

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to epinephrine [inference]

cellular response to epinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to salt [inference]

response to calcium ion

detection of calcium ion

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of calcium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

cellular response to oxygen-containing compound [inference]

cellular response to catecholamine stimulus [inference]

cellular response to epinephrine stimulus

response to redox state

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

manganese ion transport [inference]

manganese ion transmembrane transport

calcium ion transport

sarcoplasmic reticulum calcium ion transport

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

manganese ion transmembrane transport

organic substance transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transport into cytosol

establishment of protein localization [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

establishment of protein localization [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

cell-cell signaling involved in cardiac conduction [inference]

Purkinje myocyte to ventricular cardiac muscle cell signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

positive regulation of sequestering of calcium ion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of sequestering of calcium ion

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cell communication [inference]

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of cellular process [inference]

positive regulation of sequestering of calcium ion

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

positive regulation of sequestering of calcium ion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction [inference]

positive regulation of the force of heart contraction

regulation of heart rate

positive regulation of heart rate

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of cardiac muscle contraction

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac muscle cell contraction [inference]

regulation of cardiac conduction [inference]

regulation of atrial cardiac muscle cell action potential

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

positive regulation of multicellular organismal process [inference]

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of heart rate

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of biological quality [inference]

regulation of the force of heart contraction [inference]

positive regulation of the force of heart contraction

regulation of heart rate

positive regulation of heart rate

positive regulation of cytosolic calcium ion concentration [inference]

calcium ion transport into cytosol

regulation of membrane potential [inference]

action potential [inference]

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction [inference]

ventricular cardiac muscle cell action potential

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

negative regulation of cytosolic calcium ion concentration

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
nuclear envelope	IDA	11590243
smooth endoplasmic reticulum	ISO
smooth endoplasmic reticulum	IBA
membrane	ISO
sarcoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

sarcolemma

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
ryanodine-sensitive calcium-release channel activity	ISO
ryanodine-sensitive calcium-release channel activity	IDA	18799678
ryanodine-sensitive calcium-release channel activity	IMP	21807619
ryanodine-sensitive calcium-release channel activity	IBA
ryanodine-sensitive calcium-release channel activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

binding [inference]

protein binding

calmodulin binding

enzyme binding

kinase binding [inference]

protein kinase binding

protein kinase A catalytic subunit binding

identical protein binding

protein kinase A binding [inference]

scaffold protein binding

amide binding [inference]

suramin binding

small molecule binding [inference]

organic acid binding [inference]

suramin binding

ion binding [inference]

anion binding [inference]

suramin binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding

suramin binding

sulfur compound binding [inference]

suramin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ryanodine receptor

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
calcium-mediated signaling
intracellular calcium ion homeostasis
monoatomic ion channel activity
monoatomic ion transport
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
ryanodine-sensitive calcium-release channel activity
striated muscle contraction

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InterPro
B30.2/SPRY domain superfamily
B30.2/SPRY domain
Concanavalin A-like lectin/glucanase domain superfamily
EF-hand domain pair
Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion transport domain
MIR motif
Mir domain superfamily
RIH domain
RyR/IP3 receptor binding core, RIH domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 6** entries
Location	References
Z disc	PMID:15010472 PMID:15980179 PMID:17627991
sarcolemma	PMID:21474431
A band	PMID:17627991
protein-containing complex	PMID:16306226
sarcoplasmic reticulum	PMID:21807619
extrinsic component of cytoplasmic side of plasma membrane	PMID:20177054

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Monodelphis domestica	100028207	MONDO12708
Equus caballus	100057437	HORSE18201
Ornithorhynchus anatinus	100084273	ORNAN10806
Pongo abelii	100173051	PONAB18453
Taeniopygia guttata	100225109	TAEGU20529
Callithrix jacchus	100406916	CALJA17016
Ailuropoda melanoleuca	100476576	AILME08262
Nomascus leucogenys	100598810	NOMLE30864
Loxodonta africana	100676989	LOXAF13792
Oreochromis niloticus	100693556	ORENI71246

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements