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MIRAGE
T-box transcription factor 2

Summary
Gene Symbol
  • TBX2
Organism
Homo sapiens (human)
NCBI Gene
6909
PubChem
6909
Alliance of Genome Resources
Annotation
Keyword
  • DNA-binding
  • Developmental protein
  • Disease variant
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Transcription regulation
Proteins
Displaying 1 entry
UniProt Protein Name
Q13207
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 48 in total
GO Term Evidence Code PMID
negative regulation of transcription by RNA polymerase II
negative regulation of transcription by RNA polymerase II
cell fate specification
heart looping
outflow tract septum morphogenesis
GO Hierarchy
Displaying entries 1 - 5 of 11 in total
GO Term Evidence Code PMID
RNA polymerase II cis-regulatory region sequence-specific DNA binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription repressor activity, RNA polymerase II-specific
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Transcription factor T-box
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying 1 entry
Gene Ontology
cell fate specification
Displaying all 6 entries
InterPro
T-box superfamily
T-box transcription factor 2/3, transcription activation domain
T-box transcription factor, DNA-binding domain
T-box transcription factor
Transcription factor, T-box, conserved site
p53-like transcription factor, DNA-binding domain superfamily
Disease
Disease Ontology
Displaying all 3 entries
DO ID Disease Name Source
DOID:0070345 vertebral anomalies and variable endocrine and T-cell dysfunction
DOID:1681 heart septal defect
DOID:1882 atrial heart septal defect
Ortholog
Displaying entries 1 - 10 of 66 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
6909 Xenbase:XB-GENE-1018115
6926 FB:FBgn0000179
21385 MOUSE06148
21386 FB:FBgn0000179
30253 DANRE08297
303398 RATNO00527
454800 PANTR15103
535982 BOVIN12197
716277 MACMU14206
100010007 MONDO11864
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025