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MIRAGE
HNF1 homeobox A

Summary
Gene Symbol
  • HNF1A
Organism
Homo sapiens (human)
NCBI Gene
6927
PubChem
6927
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • DNA-binding
  • Diabetes mellitus
  • Disease variant
  • Homeobox
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transcription regulation
  • Ubl conjugation
Proteins
Displaying all 4 entries
UniProt Protein Name
E0YMI7
P20823
  • Liver-specific transcription factor LF-B1
  • Transcription factor 1
A0A0A0MTK8
F5H0K0
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 14 in total
GO Term Evidence Code PMID
liver development
regulation of transcription by RNA polymerase II
regulation of transcription by RNA polymerase II
insulin secretion
insulin secretion
GO Hierarchy
Displaying entries 1 - 5 of 11 in total
GO Term Evidence Code PMID
transcription cis-regulatory region binding
RNA polymerase II cis-regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Hepatocyte nuclear factor 1-beta
Functional Category
  • I: Lipid transport and metabolism
  • K: Transcription
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 3 entries
Gene Ontology
insulin secretion
liver development
pancreas development
Displaying all 9 entries
InterPro
HNF-1, POU-specific (POUs) atypical domain
HNF-1, dimerization domain
Hepatocyte nuclear factor 1, N-terminal domain superfamily
Hepatocyte nuclear factor 1, N-terminal
Hepatocyte nuclear factor 1, beta isoform, C-terminal
Hepatocyte nuclear factor 1
Homeobox domain
Homeobox-like domain superfamily
Lambda repressor-like, DNA-binding domain superfamily
Disease
Disease Ontology
Displaying entries 1 - 10 of 15 in total
DO ID Disease Name Source
DOID:0050524 maturity-onset diabetes of the young
DOID:0050868 hepatocellular adenoma
DOID:0110757 type 1 diabetes mellitus 20
DOID:0111102 maturity-onset diabetes of the young type 3
DOID:0111366 familial hepatic adenoma
DOID:10591 pre-eclampsia
DOID:10603 glucose intolerance
DOID:11714 gestational diabetes
DOID:3393 coronary artery disease
DOID:3526 cerebral infarction
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025