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Guidelines

MIRAGE

phenoloxidase subunit 1

Summary

Gene Symbol

PPO1

Organism

Bombyx mori (domestic silkworm)

External Links

NCBI Gene: 692758
PubChem: 692758

Annotation

Keyword

Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Melanin biosynthesis
Metal-binding
Monooxygenase
Reference proteome
Secreted
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q27451	PO 1 Tyrosinase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
melanin biosynthetic process from tyrosine
defense response

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

pigment biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

response to stimulus [inference]

response to stress [inference]

defense response

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular region

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tyrosinase activity
oxidoreductase activity	IEA	22301074
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phenoloxidase 2

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
metal ion binding
oxidoreductase activity

Displaying **all 9** entries
InterPro
Di-copper centre-containing domain superfamily
Hemocyanin, C-terminal domain superfamily
Hemocyanin, C-terminal
Hemocyanin, N-terminal domain superfamily
Hemocyanin, N-terminal
Hemocyanin/hexamerin middle domain
Hemocyanin/hexamerin
Immunoglobulin E-set
Tyrosinase copper-binding domain

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025