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treacle ribosome biogenesis factor 1

Summary

Gene Symbol

TCOF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6949

PubChem

6949

Alliance of Genome Resources

HGNC:11654

JoGo

TCOF1

TogoVar

TCOF1

Annotation

Keyword

Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E7ETY2
B4DRA2
Q13428	Treacher Collins syndrome protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
skeletal system development	TAS	9096354
regulation of translation	IMP	26399832
neural crest formation	IMP	26399832
neural crest cell development	IMP	26399832
nucleolar large rRNA transcription by RNA polymerase I	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

neural crest formation

anatomical structure development [inference]

cell development [inference]

stem cell development [inference]

neural crest cell development

system development [inference]

skeletal system development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fibrillar center	IDA
nucleoplasm	IDA
nucleolus	IDA	15249688 23203802
nucleolus	IBA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
protein binding	IPI	17620599 23602568 25064736 26399832 32707033 32814053 36411431
protein-macromolecule adaptor activity	IDA	26399832
protein heterodimerization activity	IPI	26399832
scaffold protein binding	IBA