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GO Term	Evidence Code	PMID
cytosol	IEA
cyclin/CDK positive transcription elongation factor complex	IBA
nuclear speck	ISS
nuclear speck	ISO
nuclear cyclin-dependent protein kinase holoenzyme complex	IDA	17261272

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription elongation factor complex [inference]

cyclin/CDK positive transcription elongation factor complex

nuclear cyclin-dependent protein kinase holoenzyme complex

cyclin/CDK positive transcription elongation factor complex

carboxy-terminal domain protein kinase complex [inference]

cyclin/CDK positive transcription elongation factor complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

cyclin-dependent protein kinase holoenzyme complex [inference]

cyclin K-CDK13 complex

nuclear cyclin-dependent protein kinase holoenzyme complex

cyclin/CDK positive transcription elongation factor complex

carboxy-terminal domain protein kinase complex [inference]

cyclin/CDK positive transcription elongation factor complex

cellular anatomical entity [inference]

cytosol

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cyclin-dependent protein serine/threonine kinase activity	IEA
ATP binding	IEA
RNA polymerase II CTD heptapeptide repeat kinase activity	ISS
RNA polymerase II CTD heptapeptide repeat kinase activity	ISO
RNA polymerase II CTD heptapeptide repeat kinase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

RNA polymerase II CTD heptapeptide repeat kinase activity

cyclin-dependent protein kinase activity [inference]

cyclin-dependent protein serine/threonine kinase activity

protein serine kinase activity

RNA polymerase II CTD heptapeptide repeat modifying activity [inference]

RNA polymerase II CTD heptapeptide repeat kinase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

cyclin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cyclin-dependent kinase 12

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
RNA polymerase II CTD heptapeptide repeat kinase activity
cyclin binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112247	congenital heart defects, dysmorphic facial features, and intellectual developmental disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 44 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8621	Xenbase:XB-GENE-6040279
Saccharomyces cerevisiae S288C	51755	SGD:S000001622
Saccharomyces cerevisiae S288C	69131	SGD:S000001622
Xenopus tropicalis	69562	Xenbase:XB-GENE-6040279
Rattus norvegicus	306998		RATNO12524
Canis lupus familiaris	475874		CANLF05502
Bos taurus	511147		BOVIN28292
Macaca mulatta	711379		MACMU33317
Equus caballus	100063603		HORSE32071
Taeniopygia guttata	100229652		TAEGU17765

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Acknowledgements