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Guidelines

MIRAGE

peroxidasin

Summary

Gene Symbol

Pxdn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

69675

PubChem

69675

Alliance of Genome Resources

MGI:1916925

Annotation

Keyword

Basement membrane
Calcium
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Heme
Hydrogen peroxide
Immunoglobulin domain
Leucine-rich repeat
Phosphoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3UQ28

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
angiogenesis	ISS
angiogenesis	ISO
eye development	IMP	31817535
response to oxidative stress	IEA
cell adhesion	IMP	24895407

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular process [inference]

cell adhesion

cellular metabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

supramolecular fiber organization [inference]

collagen fibril organization

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
basement membrane	IDA	22842973
extracellular space	ISS
extracellular space	ISO
extracellular space	IBA
extracellular space	HDA	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
peroxidase activity	ISS
peroxidase activity	ISO
peroxidase activity	IBA
extracellular matrix structural constituent	RCA	22159717 28071719
extracellular matrix structural constituent	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor

peroxidase activity

lactoperoxidase activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

laminin binding [inference]

laminin-1 binding

ion binding [inference]

cation binding [inference]

metal ion binding

extracellular matrix binding [inference]

laminin binding [inference]

laminin-1 binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

lactoperoxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peroxidasin

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress

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InterPro
Cysteine-rich flanking region, C-terminal
Haem peroxidase domain superfamily, animal type
Haem peroxidase superfamily
Haem peroxidase, animal-type
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	4025	FB:FBgn0011828
Drosophila melanogaster	4353	FB:FBgn0011828
Homo sapiens	7837	Xenbase:XB-GENE-923300	HUMAN61333
Drosophila melanogaster	8288	FB:FBgn0011828
Drosophila melanogaster	13861	FB:FBgn0011828
Drosophila melanogaster	17523	FB:FBgn0011828
Xenopus tropicalis	38326	Xenbase:XB-GENE-923300
Xenopus tropicalis	69675	Xenbase:XB-GENE-923300
Drosophila melanogaster	137902	FB:FBgn0011828
Xenopus tropicalis	181288	Xenbase:XB-GENE-923300

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025