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BUB1 mitotic checkpoint serine/threonine kinase B

Summary

Gene Symbol

BUB1B

Organism

Homo sapiens (human)

External Links

NCBI Gene

701

PubChem

701

Alliance of Genome Resources

HGNC:1149

JoGo

BUB1B

TogoVar

BUB1B

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Apoptosis
Centromere
Chromosome
Cytoskeleton
Disease variant
Kinetochore
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Serine/threonine-protein kinase
Tumor suppressor
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O60566	MAD3/BUB1-related protein kinase Mitotic checkpoint kinase MAD3L Protein SSK1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
apoptotic process	IEA
metaphase/anaphase transition of mitotic cell cycle	IEA
mitotic spindle assembly checkpoint signaling	NAS	11535616
mitotic spindle assembly checkpoint signaling	IDA	10477750

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

cell death [inference]

programmed cell death [inference]

apoptotic process

cell cycle process [inference]

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

metaphase/anaphase transition of mitotic cell cycle

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic cell cycle phase transition [inference]

metaphase/anaphase transition of mitotic cell cycle

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

cell division

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion [inference]

meiotic sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

centromeric sister chromatid cohesion [inference]

meiotic sister chromatid cohesion, centromeric

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromosome, centromeric region

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome organization [inference]

regulation of sister chromatid segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome organization [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome segregation [inference]

regulation of sister chromatid segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

metaphase/anaphase transition of cell cycle [inference]

metaphase/anaphase transition of mitotic cell cycle

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of chromosome separation [inference]

regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

regulation of metaphase/anaphase transition of cell cycle [inference]

regulation of mitotic metaphase/anaphase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome segregation [inference]

negative regulation of sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid segregation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of chromosome separation [inference]

negative regulation of mitotic sister chromatid separation [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

spindle checkpoint signaling [inference]

spindle assembly checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of metaphase/anaphase transition of cell cycle [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic spindle checkpoint signaling [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic nuclear division [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of mitotic metaphase/anaphase transition [inference]

mitotic spindle assembly checkpoint signaling

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA	12925705 17227893 17363900 19465021 20220147 22331848 9660858 9763420
kinetochore	IBA
outer kinetochore	IDA	19468067 22331848
nucleus	IBA
anaphase-promoting complex	TAS	10477750

GO Hierarchy

cellular component

protein-containing complex [inference]

outer kinetochore

nuclear protein-containing complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

mitotic checkpoint complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

nuclear ubiquitin ligase complex [inference]

anaphase-promoting complex

cullin-RING ubiquitin ligase complex [inference]

anaphase-promoting complex

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

perinuclear region of cytoplasm

supramolecular complex [inference]

kinetochore

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
protein kinase activity	NAS	9763420
protein kinase activity	IBA
3-phosphoinositide-dependent protein kinase activity	IEA
DNA-dependent protein kinase activity	IEA
AMP-activated protein kinase activity	IEA