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Guidelines

MIRAGE

solute carrier family 44, member 4

Summary

Gene Symbol

Slc44a4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

70129

PubChem

70129

Alliance of Genome Resources

MGI:1917379

Annotation

Keyword

Antiport
Cell membrane
Glycoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q91VA1	Solute carrier family 44 member 4 Thiamine pyrophosphate transporter 1
Q3TL93
Q3ULA4

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
acetylcholine biosynthetic process	ISS
acetylcholine biosynthetic process	ISO
choline transport	ISS
choline transport	ISO
choline transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance metabolic process [inference]

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

cellular process [inference]

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

neuromast hair cell development

transmembrane transport [inference]

vitamin transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

export from cell [inference]

secretion by cell [inference]

signal release [inference]

acetylcholine secretion

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

otolith formation

anatomical structure development [inference]

cell development [inference]

neuron development [inference]

neuromast hair cell development

cellular developmental process [inference]

cell development [inference]

neuron development [inference]

neuromast hair cell development

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

signal release [inference]

acetylcholine secretion

vitamin transport [inference]

thiamine transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

transmembrane transport [inference]

vitamin transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

acetylcholine transport [inference]

acetylcholine secretion

choline transport

thiamine transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

quaternary ammonium group transport [inference]

acetylcholine transport [inference]

acetylcholine secretion

organic anion transport [inference]

thiamine pyrophosphate transmembrane transport

organophosphate ester transport [inference]

thiamine pyrophosphate transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

acetate ester transport [inference]

acetylcholine transport [inference]

acetylcholine secretion

nitrogen compound transport

quaternary ammonium group transport [inference]

acetylcholine transport [inference]

acetylcholine secretion

thiamine transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

sulfur compound transport [inference]

thiamine transport [inference]

thiamine transmembrane transport [inference]

thiamine pyrophosphate transmembrane transport

export from cell [inference]

secretion by cell [inference]

signal release [inference]

acetylcholine secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
apical plasma membrane	ISS
apical plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
organic cation transmembrane transporter activity
choline transmembrane transporter activity	ISS
choline transmembrane transporter activity	ISO
antiporter activity	IEA
thiamine pyrophosphate transmembrane transporter activity	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

organic cation transmembrane transporter activity

thiamine transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity [inference]

organophosphate ester transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

vitamin transmembrane transporter activity [inference]

thiamine transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

azole transmembrane transporter activity [inference]

thiamine transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

thiamine transmembrane transporter activity [inference]

thiamine pyrophosphate transmembrane transporter activity

salt transmembrane transporter activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Choline transporter-like

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Choline transporter-like

Ortholog

Displaying entries **1 - 10** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	43440	Xenbase:XB-GENE-485457
Drosophila melanogaster	57153	FB:FBgn0039637
Drosophila melanogaster	68682	FB:FBgn0039637
Xenopus tropicalis	70129	Xenbase:XB-GENE-485457
Homo sapiens	80736	Xenbase:XB-GENE-485457	HUMAN84065
Xenopus tropicalis	180809	Xenbase:XB-GENE-485457
Drosophila melanogaster	204962	FB:FBgn0039637
Drosophila melanogaster	242259	FB:FBgn0039637
Rattus norvegicus	294255	Xenbase:XB-GENE-485457	RATNO22468
Drosophila melanogaster	321056	FB:FBgn0039637

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025