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transforming growth factor beta induced

Summary

Gene Symbol

TGFBI

Organism

Homo sapiens (human)

External Links

NCBI Gene

7045

PubChem

7045

Alliance of Genome Resources

HGNC:11771

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Cell adhesion
Corneal dystrophy
Direct protein sequencing
Disease variant
Disulfide bond
Extracellular matrix
Gamma-carboxyglutamic acid
Phosphoprotein
Reference proteome
Repeat
Signal
Vision

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z4Q2
Q15582	Kerato-epithelin RGD-containing collagen-associated protein

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cell population proliferation	TAS	1388724
negative regulation of cell adhesion	TAS	8024701
chondrocyte differentiation	IEA
visual perception	IEA
cell adhesion	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion

negative regulation of cellular process [inference]

negative regulation of cell adhesion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular matrix	IBA
collagen-containing extracellular matrix	HDA ISS	20551380 22261194 23979707 25037231 27559042 28327460 28675934
plasma membrane	TAS
basement membrane	IEA
extracellular region	HDA TAS	27068509

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
protein binding	IPI	18083624 19478074 25416956 25853243 32296183
integrin binding	TAS	1388724
extracellular matrix structural constituent	ISS RCA	20551380 23979707 25037231 27559042 28327460 28675934
extracellular matrix binding	IEA
identical protein binding	IPI	31197037

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

identical protein binding

cell adhesion molecule binding

integrin binding

protein-containing complex binding [inference]

extracellular matrix binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Fasciclin-like arabinogalactan protein

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
InterPro
FAS1 domain superfamily
FAS1 domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060444	granular corneal dystrophy 2	Alliance of Genome Resources
DOID:0060447	epithelial basement membrane dystrophy	Alliance of Genome Resources
DOID:0060453	Reis-Bucklers corneal dystrophy	Alliance of Genome Resources
DOID:0060455	Thiel-Behnke corneal dystrophy	Alliance of Genome Resources
DOID:0080530	granular corneal dystrophy 1	Alliance of Genome Resources
DOID:2566	corneal dystrophy	Alliance of Genome Resources
DOID:557	kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 92 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	779782		Xenbase:XB-GENE-5751247
Saccharomyces cerevisiae S288C	850687		SGD:S000003991
Oryctolagus cuniculus	100009230			RABIT09340
Monodelphis domestica	100012659			MONDO08453
Equus caballus	100072674			HORSE08482
Ornithorhynchus anatinus	100074022			ORNAN29159
Ornithorhynchus anatinus	100075791			ORNAN29159
Taeniopygia guttata	100227786			TAEGU04097
Callithrix jacchus	100397340			CALJA25818
Pongo abelii	100441300	9601_0:0018a5		PONAB29609

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UniCarb-DR

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements