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TIMP metallopeptidase inhibitor 3

Summary

Gene Symbol

TIMP3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7078

PubChem

7078

Alliance of Genome Resources

HGNC:11822

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Extracellular matrix
Metal-binding
Metalloprotease inhibitor
Reference proteome
Signal
Vision
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P35625	Protein MIG-5 Tissue inhibitor of metalloproteinases 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
visual perception	IEA
response to hormone	IBA
response to cytokine	IBA
negative regulation of membrane protein ectodomain proteolysis	IMP	18383040
negative regulation of membrane protein ectodomain proteolysis	IBA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

response to chemical [inference]

response to organic substance [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metallopeptidase activity [inference]

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metallopeptidase activity [inference]

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metallopeptidase activity [inference]

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of proteolysis [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of membrane protein ectodomain proteolysis [inference]

negative regulation of membrane protein ectodomain proteolysis

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of membrane protein ectodomain proteolysis

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

regulation of metallopeptidase activity [inference]

regulation of metalloendopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

negative regulation of metallopeptidase activity [inference]

negative regulation of metalloendopeptidase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
basement membrane	IEA
extracellular space	IBA
nucleus	HDA	21630459
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet dense granule lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protease binding
protein binding	IPI	18344519 18638486
metalloendopeptidase inhibitor activity	TAS	18638486
metalloendopeptidase inhibitor activity	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

metalloendopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Metalloproteinase inhibitor 3

Functional Category

E: Amino acid transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
metal ion binding
metalloendopeptidase inhibitor activity
negative regulation of membrane protein ectodomain proteolysis
peptidase inhibitor activity
protease binding
response to cytokine
response to hormone

Displaying **all 4** entries
InterPro
Netrin domain
Protease inhibitor I35 (TIMP)
Proteinase inhibitor I35b (TIMP), C-terminal
Tissue inhibitor of metalloproteinases-like, OB-fold

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090114	Sorsby's fundus dystrophy	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	7076	FB:FBgn0025879
Xenopus tropicalis	7078	Xenbase:XB-GENE-482400
Drosophila melanogaster	21857	FB:FBgn0025879
Mus musculus	21859	Xenbase:XB-GENE-482400	MOUSE00161
Rattus norvegicus	25358		RATNO37655
Drosophila melanogaster	116510	FB:FBgn0025879
Xenopus tropicalis	179197	Xenbase:XB-GENE-482400
Drosophila melanogaster	179199	FB:FBgn0025879
Sus scrofa	396775		PIGXX25188
Pan troglodytes	458784		PANTR26424

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OrthoDB (Group)

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Acknowledgements