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tight junction protein 1

Summary

Gene Symbol

TJP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7082

PubChem

7082

Alliance of Genome Resources

HGNC:11827

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Cell membrane
Cell projection
Developmental protein
Gap junction
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
SH3 domain
Tight junction

Proteins

Displaying **all 8** entries
UniProt	Protein Name
A0A0G2JNH2	Zonula occludens protein 1
A0A7I2V5U5	Zonula occludens protein 1
Q07157	Tight junction protein ZO-1 Zona occludens protein 1 Zonula occludens protein 1
A0A087X0K9	Zonula occludens protein 1
B4DZK4
G3V1L9	Zonula occludens protein 1
G5E9E7	Zonula occludens protein 1
A9CQZ8	Zonula occludens protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
cell-cell junction assembly	TAS	8486731
positive regulation of cell population proliferation	IMP	29771433
actin cytoskeleton organization	IMP	25753039
positive regulation of cell migration	IMP	25753039
actomyosin structure organization	IMP	25753039

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

actin filament-based process [inference]

actin cytoskeleton organization

actomyosin structure organization

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

actomyosin structure organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

cell-cell junction organization

cell-cell junction assembly

adherens junction organization [inference]

adherens junction maintenance

cell-cell junction maintenance [inference]

adherens junction maintenance

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability [inference]

positive regulation of blood-brain barrier permeability

regulation of blood-brain barrier permeability [inference]

positive regulation of blood-brain barrier permeability

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

cell development [inference]

epithelial cell development [inference]

endothelial cell development [inference]

establishment of endothelial barrier [inference]

establishment of endothelial intestinal barrier

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to cell junction [inference]

protein localization to cell-cell junction

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cell-cell adhesion mediated by cadherin [inference]

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cell junction assembly

regulation of bicellular tight junction assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cell junction assembly

regulation of bicellular tight junction assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of biological quality [inference]

regulation of vascular permeability [inference]

positive regulation of vascular permeability [inference]

positive regulation of blood-brain barrier permeability

regulation of blood-brain barrier permeability [inference]

positive regulation of blood-brain barrier permeability

Displaying entries **16 - 20** of 21 in total

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GO Term	Evidence Code	PMID
protein-containing complex	IDA	25753039
cell projection	IEA
apical junction complex	IDA	16427635
apical part of cell	IDA	22006950
tight junction	IDA	22855531 27037668 30734065

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

cell junction

anchoring junction [inference]

cell-cell junction [inference]

tight junction

bicellular tight junction

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

apical part of cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11042084 11734628 12023291 12154091 16944923 17015620 17724469 18823282 19332538 20164257 20850437 21402783 22262837 23885123 25753039 28661558 29366904 30992345 31473225 33961781 9707407
calmodulin binding	IEA
cadherin binding	HDA	25468996
cell adhesion molecule binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

calmodulin binding

cell adhesion molecule binding

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tight junction protein ZO-1

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cell adhesion molecule binding
cell-cell junction organization
establishment of endothelial intestinal barrier
positive regulation of blood-brain barrier permeability
protein localization to cell-cell junction

Displaying entries **1 - 10** of 11 in total

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InterPro
Guanylate kinase-like domain
Guanylate kinase/L-type calcium channel beta subunit
P-loop containing nucleoside triphosphate hydrolase
PDZ domain
PDZ superfamily
SH3 domain
SH3-like domain superfamily
Tight junction protein ZO-1
Tight junction protein ZO
ZO-1, SH3 domain

Ortholog

Displaying entries **11 - 20** of **123** in total

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Species	Gene ID	Orthologous MAtrix
Danio rerio	565459	DANRE27132
Macaca mulatta	720550	MACMU41744
Monodelphis domestica	100021326	MONDO08541
Equus caballus	100050412	HORSE16362
Ornithorhynchus anatinus	100078517	ORNAN21843
Taeniopygia guttata	100231257	TAEGU02138
Oryctolagus cuniculus	100346390	RABIT06601
Callithrix jacchus	100395578	CALJA38093
Pongo abelii	100446271	PONAB08674
Ailuropoda melanoleuca	100479188	AILME06617

GlyTouCan

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OrthoDB (Group)

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Acknowledgements