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tolloid like 2

Summary

Gene Symbol

TLL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7093

PubChem

7093

Alliance of Genome Resources

HGNC:11844

Annotation

Keyword

Calcium
Cleavage on pair of basic residues
Developmental protein
Differentiation
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Methylation
Reference proteome
Repeat
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y6L7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
dorsal/ventral pattern formation	IBA
protein processing	IBA
cell differentiation	IEA
collagen fibril organization	TAS
negative regulation of skeletal muscle tissue growth	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

protein maturation [inference]

protein processing

cellular process [inference]

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

dorsal/ventral pattern formation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of skeletal muscle tissue growth

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
serine-type endopeptidase activity	TAS
calcium ion binding	IEA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tolloid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion binding
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 10** entries
InterPro
Bone morphogenetic protein 1/tolloid-like protein
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Metallopeptidase, catalytic domain superfamily
Peptidase M12A
Peptidase, metallopeptidase
Spermadhesin, CUB domain superfamily

Ortholog

Displaying entries **11 - 20** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pan troglodytes	450644		PANTR01248
Drosophila melanogaster	474335	FB:FBgn0004885
Bos taurus	504975		BOVIN21265
Macaca mulatta	705290		MACMU46563
Equus caballus	100070823		HORSE17529
Ornithorhynchus anatinus	100086650		ORNAN18379
Taeniopygia guttata	100224187		TAEGU27376
Callithrix jacchus	100405295		CALJA07125
Pongo abelii	100457372		PONAB00944
Ailuropoda melanoleuca	100480828		AILME15111

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