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transmembrane serine protease 2

Summary

Gene Symbol

TMPRSS2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7113

PubChem

7113

Alliance of Genome Resources

HGNC:11876

Annotation

Keyword

3D-structure
Alternative splicing
Autocatalytic cleavage
Cell membrane
Disulfide bond
Glycoprotein
Host-virus interaction
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane helix
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
O15393	Serine protease 10

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	IDA	21068237 24227843
viral translation	TAS	27384577
protein autoprocessing	IBA IMP	21068237
positive regulation of viral entry into host cell	IDA	21068237 24227843 32404436

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

viral process [inference]

viral translation

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA TAS	21068237
extracellular region	TAS
nucleoplasm	IDA
extracellular exosome	HDA	19056867 19199708 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	21068237 32296183 33741941
serine-type peptidase activity	TAS	9325052
serine-type endopeptidase activity	IDA TAS	25122198

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Serine protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Ortholog

Displaying entries **1 - 10** of 68 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41958		FB:FBgn0003319
Mus musculus	50528		MGI:1354381	MOUSE18616
Rattus norvegicus	156435		RGD:620766	RATNO04134
Pan troglodytes	474007	9598_0:0052d8		PANTR25722
Danio rerio	494080		ZFIN:ZDB-GENE-041212-48	DANRE01650
Bos taurus	511037			BOVIN15416
Macaca mulatta	715138			MACMU32098
Monodelphis domestica	100016391			MONDO21489
Salmo salar	100195190			SALSA118913
Taeniopygia guttata	100230865			TAEGU10256