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troponin I3, cardiac type

Summary

Gene Symbol

TNNI3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7137

PubChem

7137

Alliance of Genome Resources

HGNC:11947

Annotation

Keyword

3D-structure
Acetylation
Actin-binding
Cardiomyopathy
Coiled coil
Direct protein sequencing
Disease variant
Muscle protein
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6FGX2	Cardiac troponin I
P19429	Cardiac troponin I

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
vasculogenesis	ISS
regulation of systemic arterial blood pressure by ischemic conditions	ISS
skeletal muscle contraction	IBA
intracellular calcium ion homeostasis	ISS
regulation of smooth muscle contraction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

actin filament-based process [inference]

actin filament-based movement [inference]

actin-mediated cell contraction [inference]

actin-myosin filament sliding [inference]

muscle filament sliding

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

nervous system process [inference]

nervous system process involved in regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure by ischemic conditions

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis

anatomical structure development [inference]

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

vasculogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of molecular function [inference]

regulation of ATP-dependent activity [inference]

negative regulation of ATP-dependent activity

negative regulation of molecular function [inference]

negative regulation of ATP-dependent activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
troponin complex	IDA	10806205 10850966 12093807 7957210
troponin complex	IBA
sarcomere	NAS	12840750
sarcomere	TAS	16754800

GO Hierarchy

cellular component

protein-containing complex [inference]

troponin complex

cardiac Troponin complex

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril [inference]

cardiac myofibril

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
actin binding	IDA	10806205
protein binding	IPI	10806205 12525172 12721663 12809519 12840750 16516408 18986304 21569246 23369981 25910212 28514442 29997244 32296183 32814053 33961781
calcium channel inhibitor activity	IPI	12809519
protein kinase binding	IPI	12721663
protein domain specific binding	IPI	11984006

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

protein-containing complex binding [inference]

actin filament binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

ion channel regulator activity [inference]

calcium channel regulator activity [inference]

calcium channel inhibitor activity

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

calcium channel inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

troponin i

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin binding
cardiac muscle contraction
skeletal muscle contraction

Displaying **all 2** entries
InterPro
Troponin domain superfamily
Troponin

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0110313	hypertrophic cardiomyopathy 7	Alliance of Genome Resources
DOID:0110459	dilated cardiomyopathy 1FF	Alliance of Genome Resources
DOID:0110460	dilated cardiomyopathy 2A	Alliance of Genome Resources
DOID:0111425	familial restrictive cardiomyopathy 1	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources
DOID:397	restrictive cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 37 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7137	Xenbase:XB-GENE-486987
Mus musculus	21954	Xenbase:XB-GENE-486987	MOUSE54212
Rattus norvegicus	29248	Xenbase:XB-GENE-486987	RATNO20160
Canis lupus familiaris	403566		CANLF00647
Equus caballus	100034065		HORSE01995
Sus scrofa	100049696		PIGXX28568
Ornithorhynchus anatinus	100077614		ORNAN01484
Callithrix jacchus	100389415		CALJA23789
Pongo abelii	100446190		PONAB15127
Nomascus leucogenys	100590739		NOMLE01892

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements