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DNA topoisomerase III alpha

Summary

Gene Symbol

TOP3A

Organism

Homo sapiens (human)

External Links

NCBI Gene

7156

PubChem

7156

Alliance of Genome Resources

HGNC:11992

JoGo

TOP3A

TogoVar

TOP3A

Annotation

Keyword

3D-structure
Alternative splicing
DNA-binding
Disease variant
Dwarfism
Magnesium
Mitochondrion
Progressive external ophthalmoplegia
Proteomics identification
Reference proteome
Repeat
Topoisomerase
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13472	DNA topoisomerase III alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	IDA	23543748
DNA topological change	IDA	20445207
DNA topological change	IBA
DNA repair	IBA
DNA recombination	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

cell cycle process [inference]

chromosome separation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA topological change

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA topological change

reproductive process [inference]

meiotic cell cycle

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair [inference]

double-strand break repair via homologous recombination

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	NAS	23543748
nucleus	IBA
nucleoplasm	TAS
mitochondrion	HTP	34800366
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

RecQ family helicase-topoisomerase III complex

cellular anatomical entity [inference]

nucleoplasm

nuclear body [inference]

PML body

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA binding	TAS	8622991
single-stranded DNA binding	IDA	29290614
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IDA	20445207
DNA topoisomerase type I (single strand cut, ATP-independent) activity	IBA
protein binding	IPI	10728666 15775963 16537486 20360068 20711169 20826342 23509288 24509834 26496610 33961781 35271311

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA topoisomerase activity [inference]

DNA topoisomerase type I (single strand cut, ATP-independent) activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

single-stranded DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dna topoisomerase

Functional Category

L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
DNA topoisomerase type I (single strand cut, ATP-independent) activity
DNA topological change
isomerase activity

Displaying entries **1 - 10** of 11 in total

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InterPro
DNA topoisomerase 3-like, TOPRIM domain
DNA topoisomerase, type IA, DNA-binding domain
DNA topoisomerase, type IA, active site
DNA topoisomerase, type IA, central region, subdomain 1
DNA topoisomerase, type IA, central region, subdomain 2
DNA topoisomerase, type IA, central region, subdomain 3
DNA topoisomerase, type IA, central
DNA topoisomerase, type IA, core domain
DNA topoisomerase, type IA, domain 2
DNA topoisomerase, type IA