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tumor protein p53
Summary
- Gene Symbol
-
- TP53
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Activator
- Alternative promoter usage
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell cycle
- Cytoplasm
- Cytoskeleton
- DNA-binding
- Direct protein sequencing
- Disease variant
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Isopeptide bond
- Li-Fraumeni syndrome
- Metal-binding
- Methylation
- Mitochondrion
- Necrosis
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repressor
- Transcription regulation
- Tumor suppressor
- Ubl conjugation
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A087WT22 |
|
| H2EHT1 |
|
| A0A087WXZ1 |
|
| P04637 |
|
| K7PPA8 |
|
| A0A087X1Q1 |
|
| Q53GA5 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to ischemia | ||
| DNA damage response | ||
| neuroblast proliferation |
GO Hierarchy
- viral process
- negative regulation of cell growth
- negative regulation of cell growth
biological process
immune system process [inference]
metabolic process [inference]
nitrogen compound metabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
cell activation [inference]
signal transduction [inference]
intracellular signal transduction [inference]
apoptotic signaling pathway [inference]
cellular metabolic process [inference]
cellular response to stimulus [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
response to stress [inference]
response to chemical [inference]
cellular response to stimulus [inference]
localization [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
regulation of DNA metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of programmed cell death [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell cycle [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
intracellular signal transduction [inference]
apoptotic signaling pathway [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of programmed cell death [inference]
negative regulation of cellular process [inference]
negative regulation of cellular metabolic process [inference]
negative regulation of cell cycle [inference]
regulation of cellular component organization [inference]
regulation of cell cycle
regulation of mitotic cell cycle [inference]
regulation of cell cycle process [inference]
negative regulation of cell cycle process [inference]
regulation of cell cycle phase transition [inference]
negative regulation of cell cycle [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| RNA polymerase II-specific DNA-binding transcription factor binding | ||
| DNA binding | ||
| general transcription initiation factor binding | ||
| core promoter sequence-specific DNA binding | ||
| DNA-binding transcription factor activity |
GO Hierarchy
molecular function
binding [inference]
protein binding
organic cyclic compound binding [inference]
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0001816 | angiosarcoma | |
| DOID:0002116 | pterygium | |
| DOID:0050745 | diffuse large B-cell lymphoma | |
| DOID:0050834 | CHARGE syndrome | |
| DOID:0050861 | colorectal adenocarcinoma | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0050902 | medulloblastoma | |
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0060071 | pre-malignant neoplasm |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100062044 | HORSE03645 | ||
| 397276 | PIGXX03337 | ||
| 281542 | BOVIN12761 | ||
| 102169621 | CAPHI10405 | ||
| 443421 | SHEEP02763 | ||
| 100009292 | RABIT07195 | ||
| 22059 | MGI:98834 | MOUSE05660 | |
| 24842 | RGD:3889 | RATNO03077 | |
| 100379269 | CAVPO18384 | ||
| 102448135 | PELSI05784 |
