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thyroid peroxidase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

7173

PubChem

7173

Alliance of Genome Resources

HGNC:12015

JoGo

TPO

TogoVar

TPO

Annotation

Keyword

Alternative splicing
Calcium
Congenital hypothyroidism
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Heme
Hydrogen peroxide
Proteomics identification
Reference proteome
Signal
Sushi
Thyroid hormones biosynthesis
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P07202
Q6P534
Q502Y3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
thyroid hormone generation	TAS
thyroid hormone generation	IEA
response to oxidative stress	IEA
embryonic hemopoiesis	IDA	21149635
hormone biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular process [inference]

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

cellular detoxification [inference]

cellular oxidant detoxification

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

thyroid hormone metabolic process [inference]

thyroid hormone generation

hormone biosynthetic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular space	HDA	22664934
plasma membrane	TAS
cell surface	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
iodide peroxidase activity	IEA
peroxidase activity	TAS
peroxidase activity	IBA
calcium ion binding	IEA
heme binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

haloperoxidase activity [inference]

iodide peroxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

halogenase activity [inference]

haloperoxidase activity [inference]

iodide peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

haloperoxidase activity [inference]

iodide peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	Alliance of Genome Resources
DOID:0112186	thyroid dyshormonogenesis 2A	Alliance of Genome Resources
DOID:2921	glomerulonephritis	Alliance of Genome Resources