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thyroid peroxidase
Summary
- Gene Symbol
-
- TPO
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Calcium
- Congenital hypothyroidism
- Disease variant
- Disulfide bond
- EGF-like domain
- Glycoprotein
- Heme
- Hydrogen peroxide
- Reference proteome
- Signal
- Sushi
- Thyroid hormones biosynthesis
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| thyroid hormone generation | ||
| thyroid hormone generation | ||
| response to oxidative stress | ||
| embryonic hemopoiesis | ||
| hormone biosynthetic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| extracellular space | ||
| plasma membrane | ||
| cell surface |
| GO Term | Evidence Code | PMID |
|---|---|---|
| iodide peroxidase activity | ||
| peroxidase activity | ||
| peroxidase activity | ||
| calcium ion binding | ||
| heme binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- peroxidase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| cellular oxidant detoxification |
| heme binding |
| metal ion binding |
| oxidoreductase activity |
| response to oxidative stress |
| InterPro |
|---|
| Haem peroxidase domain superfamily, animal type |
| Haem peroxidase superfamily |
| Haem peroxidase, animal-type |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0112186 | thyroid dyshormonogenesis 2A | |
| DOID:2921 | glomerulonephritis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 7173 | Xenbase:XB-GENE-920152 | ||
| 17523 | FB:FBgn0263986 | ||
| 22018 | Xenbase:XB-GENE-920152 | MOUSE08367 | |
| 54314 | RATNO35359 | ||
| 179880 | FB:FBgn0263986 | ||
| 403521 | CANLF04845 | ||
| 445522 | PIGXX22619 | ||
| 445593 | CIOIN14727 | ||
| 100072955 | HORSE10374 | ||
| 100183818 | CIOIN12624 |
