GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Blood group antigen
Cell projection
Cleavage on pair of basic residues
Complement pathway
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Inflammatory response
Phosphoprotein
Reference proteome
Secreted
Signal
Sulfation
Synapse
Systemic lupus erythematosus
Thioester bond

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P0C0L5	Basic complement C4 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
P0C0L4	Acidic complement C4 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
inflammatory response	IEA
complement activation	IGI	19302245
complement activation	IBA
complement activation, classical pathway	IEA
opsonization	TAS	22333221

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

opsonization

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

response to other organism [inference]

defense response to other organism [inference]

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to biotic stimulus [inference]

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

response to other organism [inference]

defense response to other organism [inference]

innate immune response

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

detection of molecule of bacterial origin

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of molecule of bacterial origin

detection of biotic stimulus [inference]

detection of external biotic stimulus [inference]

detection of molecule of bacterial origin

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	2395880
extracellular space	IBA
extracellular space	HDA	16502470
endoplasmic reticulum lumen

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

symbiont cell surface

cell body [inference]

neuronal cell body

blood microparticle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
complement binding	IDA	2395880
complement component C1q complex binding
endopeptidase inhibitor activity	IEA
protein binding	IPI	22071314
carbohydrate binding	IDA	2395880

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C1q complex binding

complement binding

complement component C1q complex binding

carbohydrate binding

protein-containing complex binding [inference]

complement component C1q complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying entries **1 - 10** of 11 in total

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InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin, conserved site
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding domain superfamily
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Alpha-macroglobulin-like, thiol-ester bond-forming region
Immunoglobulin-like fold
Macroglobulin domain MG3
Macroglobulin domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060298	complement component 4b deficiency	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 53 in total

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Species	Gene ID	Orthologous MAtrix
Salmo salar	106612870	SALSA145990
Bos taurus	107131209	BOVIN18735
Sinocyclocheilus grahami	107559007	SINGR82501
Ictalurus punctatus	108277767	ICTPU09810
Phascolarctos cinereus	110199439	PHACI11416
Electrophorus electricus	113582264	ELEEL30025
Bos indicus x Bos taurus	113881522	BOBOX10531
Bos indicus x Bos taurus	113881524	BOBOX10531
Salmo trutta	115163315	SALTR98953
Salmo trutta	115206254	SALTR113416

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements