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MIRAGE
transient receptor potential cation channel subfamily C member 6

Summary
Gene Symbol
  • TRPC6
Organism
Homo sapiens (human)
NCBI Gene
7225
PubChem
7225
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ANK repeat
  • Alternative splicing
  • Calcium channel
  • Cell membrane
  • Disease variant
  • Glycoprotein
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q9Y210
  • Transient receptor protein 6
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 8 in total
GO Term Evidence Code PMID
monoatomic cation transport
positive regulation of cytosolic calcium ion concentration
single fertilization
positive regulation of ion transmembrane transporter activity
regulation of cytosolic calcium ion concentration
GO Hierarchy
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
monoatomic cation channel activity
calcium channel activity
calcium channel activity
calcium channel activity
protein binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Short transient receptor potential channel
Functional Category
  • E: Amino acid transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • T: Signal transduction mechanisms
Displaying all 7 entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
inositol 1,4,5 trisphosphate binding
monoatomic ion channel activity
monoatomic ion transport
regulation of cytosolic calcium ion concentration
store-operated calcium channel activity
Displaying all 5 entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ion transport domain
Transient receptor ion channel domain
Transient receptor potential channel, canonical
Disease
Disease Ontology
Displaying all 4 entries
DO ID Disease Name Source
DOID:0080379 nephrotic syndrome type 2
DOID:0111129 focal segmental glomerulosclerosis 2
DOID:1312 focal segmental glomerulosclerosis
DOID:8544 chronic fatigue syndrome
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025