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leucine rich repeat containing 8 family, member E

Summary

Gene Symbol

Lrrc8e

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72267

PubChem

72267

Alliance of Genome Resources

MGI:1919517

Annotation

Keyword

Cell membrane
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Ion channel
Leucine-rich repeat
Lysosome
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q66JT1	Leucine-rich repeat-containing protein 8E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cell volume homeostasis	ISS
cell volume homeostasis	ISO
aspartate transmembrane transport	ISS
aspartate transmembrane transport	ISO
aspartate transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

response to abiotic stimulus [inference]

response to osmotic stress [inference]

cellular response to osmotic stress

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

cyclic-GMP-AMP transmembrane import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import into cell [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISS
cytoplasm	ISO
cytoplasm	IBA
lysosomal membrane	ISS
lysosomal membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
volume-sensitive anion channel activity	ISS
volume-sensitive anion channel activity	ISO
volume-sensitive anion channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leucine rich repeat containing 8 family member A

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
monoatomic ion transport

Displaying **all 4** entries
InterPro
LRRC8, pannexin-like TM region
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	72267	Xenbase:XB-GENE-6041092
Homo sapiens	80131	Xenbase:XB-GENE-6041092	HUMAN40319
Rattus norvegicus	304203	Xenbase:XB-GENE-6041092	RATNO05579
Xenopus tropicalis	414524	Xenbase:XB-GENE-6041092
Pan troglodytes	469115		PANTR17017
Canis lupus familiaris	485003		CANLF07924
Xenopus tropicalis	493249	Xenbase:XB-GENE-6041092
Bos taurus	507824		BOVIN32723
Macaca mulatta	706394		MACMU20217
Monodelphis domestica	100018413		MONDO20525