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ubiquitin specific peptidase 36

Summary

Gene Symbol

Usp36

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72344

PubChem

72344

Alliance of Genome Resources

MGI:1919594

Annotation

Keyword

Cytoplasm
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Thiol protease
Transferase
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
B1AQJ2	Deubiquitinating enzyme 36 Ubiquitin thioesterase 36 Ubiquitin-specific-processing protease 36

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of protein stability	IBA ISO ISS
protein stabilization	IMP	29273634
proteolysis	IEA
negative regulation of macroautophagy	ISO ISS
regulation of rRNA processing	IMP ISO ISS	29273634

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization [inference]

nucleolus organization

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization

chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of rRNA processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of rRNA processing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing

regulation of RNA metabolic process [inference]

regulation of rRNA processing

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of rRNA processing

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of rRNA processing

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of rRNA processing

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of programmed cell death [inference]

regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of biological quality [inference]

regulation of protein stability

protein stabilization

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear speck	IEA ISO
nucleoplasm	ISO
nucleus	IBA
cytosol	IBA
cytoplasm	ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
histone H2B deubiquitinase activity	IEA ISO
cysteine-type deubiquitinase activity	IBA IEA ISO
transferase activity	IEA
K48-linked deubiquitinase activity	IEA ISO
RNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

histone deubiquitinase activity [inference]

histone H2B deubiquitinase activity

K48-linked deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

histone deubiquitinase activity [inference]

histone H2B deubiquitinase activity

K48-linked deubiquitinase activity

histone modifying activity [inference]

histone deubiquitinase activity [inference]

histone H2B deubiquitinase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

ubiquitin carboxyl-terminal hydrolase 36

Functional Category

F: Nucleotide transport and metabolism
J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
hydrolase activity
proteolysis
regulation of apoptotic process

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:5426	primary ovarian insufficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **101** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38648		FB:FBgn0260936
Homo sapiens	57602		HGNC:20062	HUMAN36684
Rattus norvegicus	303700	10116_1:00393d	RGD:1309937	RATNO01010
Danio rerio	327239		ZFIN:ZDB-GENE-030131-5450	DANRE32084
Canis lupus familiaris	483344			CANLF18390
Bos taurus	504581			BOVIN13857
Macaca mulatta	710393			MACMU15730
Pan troglodytes	742992			PANTR15585
Monodelphis domestica	100026585			MONDO13793
Equus caballus	100057557			HORSE03666