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serine peptidase inhibitor, Kazal type 5

Summary

Gene Symbol

Spink5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72432

PubChem

72432

Alliance of Genome Resources

MGI:1919682

Annotation

Keyword

Disulfide bond
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q148R4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
negative regulation of antibacterial peptide production
epidermal cell differentiation	ISO
cell differentiation	IBA
regulation of cell adhesion	IMP	15466487
negative regulation of proteolysis	IMP	15466487

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

epithelial cell differentiation [inference]

epidermal cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type peptidase activity [inference]

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type peptidase activity [inference]

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type peptidase activity [inference]

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

regulation of response to external stimulus [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of response to external stimulus [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of immune response [inference]

regulation of humoral immune response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of immune response [inference]

negative regulation of humoral immune response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of antimicrobial humoral response [inference]

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response [inference]

negative regulation of antimicrobial humoral response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

regulation of defense response to bacterium [inference]

negative regulation of defense response to bacterium [inference]

negative regulation of antibacterial peptide production

regulation of cellular process [inference]

regulation of cell adhesion

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antimicrobial peptide production [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of antibacterial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of antimicrobial peptide production [inference]

negative regulation of antibacterial peptide production

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

regulation of endopeptidase activity [inference]

negative regulation of endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

regulation of serine-type peptidase activity [inference]

regulation of serine-type endopeptidase activity [inference]

negative regulation of serine-type endopeptidase activity

negative regulation of serine-type peptidase activity

negative regulation of serine-type endopeptidase activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IBA
cytoplasm	ISO
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

cytoplasm

cell cortex

cytosol

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

epidermal lamellar body

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

epidermal lamellar body

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

lamellar body [inference]

epidermal lamellar body

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	ISO
serine-type endopeptidase inhibitor activity	IBA
peptidase inhibitor activity	IMP	15466487

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Kazal-type serine protease inhibitor

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Kazal domain superfamily
Kazal domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050474	Netherton syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 36 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	11005		HUMAN81574
Homo sapiens	72432	HGNC:15464
Rattus norvegicus	361319		RATNO13638
Pan troglodytes	462173		PANTR36497
Canis lupus familiaris	478055		CANLF06691
Bos taurus	526637		BOVIN33695
Macaca mulatta	709424		MACMU39746
Drosophila melanogaster	3565243	FB:FBgn0052354
Oryctolagus cuniculus	100337963		RABIT09454
Callithrix jacchus	100403504		CALJA25036

GlyTouCan

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LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements