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uveal autoantigen with coiled-coil domains and ankyrin repeats

Summary

Gene Symbol

Uaca

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72565

PubChem

72565

Alliance of Genome Resources

MGI:1919815

Annotation

Keyword

ANK repeat
Acetylation
Alternative splicing
Coiled coil
Cytoskeleton
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0R4J0S7
Q8CGB3	Nuclear membrane-binding protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
protein import into nucleus	IMP	15271982
intrinsic apoptotic signaling pathway in response to DNA damage	IMP	15271982
intrinsic apoptotic signaling pathway in response to DNA damage	IBA
intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	15271982
intrinsic apoptotic signaling pathway in response to oxidative stress	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response

regulation of inflammatory response [inference]

negative regulation of inflammatory response

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intrinsic apoptotic signaling pathway [inference]

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

negative regulation of canonical NF-kappaB signal transduction

regulation of non-canonical NF-kappaB signal transduction [inference]

negative regulation of non-canonical NF-kappaB signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of nucleocytoplasmic transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of protein localization [inference]

positive regulation of protein localization to nucleus [inference]

positive regulation of protein import into nucleus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein import into nucleus

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	15271982
nucleus	IBA
nuclear envelope	IDA	12761289 14961764
nucleoplasm	ISO
cytoplasm	IDA	12761289 14961764

GO Hierarchy

cellular component

protein-containing complex [inference]

apoptosome

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
actin binding	IEA
protein binding	IPI	14961764 23624502
transcription regulator inhibitor activity	IMP	14961764

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transcription regulator inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Uveal autoantigen with coiled-coil domain and ankyrin repeats

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Ankyrin repeat-containing domain superfamily
Ankyrin repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 98 in total

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Species	Gene ID	Orthologous MAtrix
Tursiops truncatus	101319056	TURTR13901
Octodon degus	101562959	OCTDE07376
Jaculus jaculus	101602442	JACJA18529
Mustela putorius furo	101676118	MUSPF10931
Heterocephalus glaber	101697156	HETGA03873
Melopsittacus undulatus	101870694	MELUD19973
Chrysemys picta bellii	101940044	CHRPI14440
Ictidomys tridecemlineatus	101978538	ICTTR13136
Chinchilla lanigera	102011161	CHILA13105
Macaca fascicularis	102142386	MACFA38120

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OrthoDB (Group)

International Collaboration

Acknowledgements