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TNF superfamily member 4
Summary
- Gene Symbol
-
- TNFSF4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cytokine
- Disulfide bond
- Glycoprotein
- Proteomics identification
- Reference proteome
- Signal-anchor
- Systemic lupus erythematosus
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A024R937 |
|
| P23510 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of cytokine production | ||
| defense response to nematode | ||
| acute inflammatory response | ||
| positive regulation of immunoglobulin production | ||
| positive regulation of T cell cytokine production |
GO Hierarchy
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- signal transduction
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- positive regulation of chemokine production
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of interleukin-4 production
- positive regulation of interleukin-6 production
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
negative regulation of immune system process [inference]
positive regulation of immune system process [inference]
positive regulation of leukocyte activation [inference]
positive regulation of immune effector process [inference]
positive regulation of immune response [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
positive regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
positive regulation of lymphocyte activation [inference]
regulation of immune effector process [inference]
positive regulation of immune effector process [inference]
regulation of production of molecular mediator of immune response [inference]
regulation of leukocyte mediated immunity [inference]
regulation of immune response [inference]
regulation of adaptive immune response
regulation of T-helper cell differentiation [inference]
positive regulation of immune response [inference]
regulation of hemopoiesis [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of DNA metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of leukocyte activation [inference]
positive regulation of immune effector process [inference]
positive regulation of immune response [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
positive regulation of cell activation [inference]
negative regulation of biological process [inference]
negative regulation of immune system process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of developmental process [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response
regulation of T-helper cell differentiation [inference]
positive regulation of immune response [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
negative regulation of developmental process [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
negative regulation of cell adhesion [inference]
regulation of cell-cell adhesion [inference]
negative regulation of cell-cell adhesion [inference]
positive regulation of cell-cell adhesion [inference]
regulation of leukocyte cell-cell adhesion [inference]
positive regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of production of molecular mediator of immune response [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
negative regulation of cell differentiation [inference]
positive regulation of cell differentiation [inference]
regulation of cell development [inference]
regulation of hemopoiesis [inference]
positive regulation of cellular process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression [inference]
positive regulation of cytokine production
positive regulation of cell differentiation [inference]
positive regulation of cell adhesion [inference]
positive regulation of cell activation [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
positive regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
positive regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
negative regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of lymphocyte differentiation [inference]
regulation of T cell activation [inference]
regulation of T cell differentiation [inference]
regulation of alpha-beta T cell activation [inference]
positive regulation of alpha-beta T cell activation [inference]
regulation of alpha-beta T cell differentiation [inference]
regulation of CD4-positive, alpha-beta T cell activation [inference]
positive regulation of T cell activation [inference]
negative regulation of lymphocyte activation [inference]
positive regulation of lymphocyte activation [inference]
negative regulation of cell activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
positive regulation of cell activation [inference]
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of hemopoiesis [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| extracellular space | ||
| plasma membrane | ||
| plasma membrane | ||
| cell surface |
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor binding | ||
| cytokine activity | ||
| tumor necrosis factor receptor binding | ||
| protein binding | ||
| tumor necrosis factor receptor superfamily binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- tumor necrosis factor ligand superfamily member 4
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Tumor necrosis factor ligand superfamily member 4 |
| Tumour necrosis factor-like domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:5844 | myocardial infarction |
