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MIRAGE
signal peptide peptidase like 2B

Summary
Gene Symbol
  • Sppl2b
Organism
Mus musculus (house mouse)
NCBI Gene
73218
PubChem
73218
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Cell membrane
  • Endosome
  • Glycoprotein
  • Golgi apparatus
  • Lysosome
  • Protease
  • Reference proteome
  • Signal
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q3TD49
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 9 in total
GO Term Evidence Code PMID
membrane protein ectodomain proteolysis
membrane protein ectodomain proteolysis
membrane protein intracellular domain proteolysis
membrane protein intracellular domain proteolysis
membrane protein proteolysis
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
signal peptide peptidase-like
Functional Category
  • E: Amino acid transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • O: Posttranslational modification, protein turnover, chaperones
Displaying all 3 entries
Gene Ontology
aspartic endopeptidase activity, intramembrane cleaving
hydrolase activity
membrane protein proteolysis
Displaying all 3 entries
InterPro
PA domain
Peptidase A22B, signal peptide peptidase
Presenilin/signal peptide peptidase
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026