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izumo sperm-egg fusion 1

Summary

Gene Symbol

Izumo1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

73456

PubChem

73456

Alliance of Genome Resources

MGI:1920706

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Fertilization
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D9J7	Oocyte binding/fusion factor Sperm-specific protein izumo

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
syncytium formation by plasma membrane fusion	IMP	36394541
cell adhesion	IC	15759005
signal transduction	IEA
single fertilization
fusion of sperm to egg plasma membrane involved in single fertilization	ISO

GO Hierarchy

biological process

cellular process [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion

cell adhesion

cell-cell adhesion [inference]

heterotypic cell-cell adhesion

signal transduction

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cell-cell fusion [inference]

syncytium formation by plasma membrane fusion

reproductive process [inference]

fertilization [inference]

single fertilization

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

sperm-egg recognition

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

syncytium formation [inference]

syncytium formation by plasma membrane fusion

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

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GO Term	Evidence Code	PMID
acrosomal vesicle	IDA	20421979 31672133 32529245
acrosomal membrane	IDA	19144954 20375058 27624483
acrosomal membrane	IBA
endoplasmic reticulum membrane	IDA	35960805
plasma membrane	IDA	27624483 35960805 36394541

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-cell adhesion

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
signaling receptor binding	IBA
signaling receptor binding	IPI	24739963
protein binding	IPI	20421979 27416963 30517645 31672133 35960805 36394541
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor ligand activity

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

protein binding involved in heterotypic cell-cell adhesion

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

izumo sperm-egg fusion protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fusion of sperm to egg plasma membrane involved in single fertilization
protein binding involved in heterotypic cell-cell adhesion
signaling receptor binding
sperm-egg recognition

Displaying **all 4** entries
InterPro
Immunoglobulin-like domain superfamily
Izumo protein, immunoglobulin domain
Izumo sperm-egg fusion protein 1
Izumo sperm-egg fusion protein

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	73456	HGNC:28539
Homo sapiens	284359	HGNC:28539	HUMAN44865
Homo sapiens	499152	HGNC:28539
Canis lupus familiaris	612013		CANLF00839
Bos taurus	618057		BOVIN11466
Macaca mulatta	718234		MACMU18084
Equus caballus	100054454		HORSE01012
Ovis aries	100302705		SHEEP05637
Danio rerio	100329365		DANRE43810
Callithrix jacchus	100404750		CALJA24551