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complement C9

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

735

PubChem

735

Alliance of Genome Resources

HGNC:1358

Annotation

Keyword

3D-structure
Age-related macular degeneration
Complement alternate pathway
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Phosphoprotein
Reference proteome
Secreted
Signal
Target cell membrane
Transmembrane beta strand

Proteins

Displaying 1 entry
UniProt	Protein Name
P02748

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell killing	IDA	26841934 30111885
complement activation	IBA
complement activation, alternative pathway	IEA
complement activation, classical pathway	IEA
killing of cells of another organism	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell killing

killing of cells of another organism

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

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GO Term	Evidence Code	PMID
extracellular region	TAS
membrane attack complex	IDA	22832194 26841934
membrane attack complex	IBA
membrane attack complex	IPI	30552328
extracellular space	IDA	22832194 26841934

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

other organism part [inference]

other organism cell membrane

blood microparticle

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 32814053 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
complement activation, alternative pathway
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying **all 8** entries
InterPro
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060303	complement component 9 deficiency	Alliance of Genome Resources
DOID:0110027	age related macular degeneration 15	Alliance of Genome Resources
DOID:2559	opiate dependence	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	735	Xenbase:XB-GENE-968660
Mus musculus	12279	Xenbase:XB-GENE-968660	MOUSE15167
Rattus norvegicus	117512	Xenbase:XB-GENE-968660	RATNO23988
Canis lupus familiaris	479354		CANLF14994
Bos taurus	526766		BOVIN16020
Danio rerio	554141		DANRE36436
Macaca mulatta	694223		MACMU39778
Oryctolagus cuniculus	100009197		RABIT01925
Monodelphis domestica	100019108		MONDO18394
Equus caballus	100034183		HORSE20229

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements