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mannosidase alpha class 1C member 1

Summary

Gene Symbol

MAN1C1

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 736491
KEGG Gene ID: ptr:736491
PubChem: 736491

Annotation

Keyword

Calcium
Disulfide bond
Glycosidase
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
K7CMV7
A0A6D2XS21

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mannose trimming involved in glycoprotein ERAD pathway	IEA	30032202
carbohydrate metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

mannose trimming involved in glycoprotein ERAD pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi membrane	IEA	30032202
endoplasmic reticulum	IEA	30032202
extracellular exosome	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA	22301074
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
calcium ion binding
glycoprotein metabolic process
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
metal ion binding

Displaying **all 3** entries
InterPro
Glycoside hydrolase family 47
Seven-hairpin glycosidases
Six-hairpin glycosidase-like superfamily

KEGG BRITE Database

Orthology

K01230

Name

mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R12479	3.2.1.113	G40702WU	G55220VL

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	57134	9606_0:00005a		HUMAN48163
Mus musculus	230815			MOUSE40801
Rattus norvegicus	362625			RATNO32767
Canis lupus familiaris	478178			CANLF07006
Bos taurus	615012			BOVIN25161
Macaca mulatta	719686			MACMU25356
Equus caballus	100057488			HORSE27309
Ornithorhynchus anatinus	100082150			ORNAN07483
Taeniopygia guttata	100221810			TAEGU13593
Callithrix jacchus	100411429			CALJA39462

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024