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uromodulin

Summary

Gene Symbol

UMOD

Aliases

Tamm-Horsfall glycoprotein
uromucoid

Organism

Homo sapiens (human)

External Links

NCBI Gene

7369

HGNC

12559

KEGG Gene ID

hsa:7369

PubChem

7369

Alliance of Genome Resources

HGNC:12559

JoGo

UMOD

TogoVar

UMOD

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Ciliopathy
Cilium
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
GPI-anchor
Innate immunity
Nephronophthisis
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P07911	Tamm-Horsfall urinary glycoprotein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 47 in total

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GO Term	Evidence Code	PMID
organ or tissue specific immune response	IEA
renal water homeostasis	IEA
glomerular filtration	IEA
lipid metabolic process	IEA
intracellular calcium ion homeostasis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

cellular catabolic process [inference]

autophagy

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

cellular catabolic process [inference]

autophagy

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

lipid metabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

lipid metabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

protein folding [inference]

chaperone-mediated protein folding

cell adhesion [inference]

cell-cell adhesion [inference]

leukocyte cell-cell adhesion

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

cellular catabolic process [inference]

autophagy

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to cell periphery [inference]

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

transmembrane transport [inference]

urea transmembrane transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

membrane organization [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

renal sodium ion transport [inference]

renal sodium ion absorption

renal absorption [inference]

renal sodium ion absorption

renal filtration [inference]

glomerular filtration

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

micturition

renal tubular secretion [inference]

renal urate salt excretion

multicellular organismal response to stress

tissue remodeling [inference]

connective tissue replacement

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric epithelium development [inference]

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

collecting duct development

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

juxtaglomerular apparatus development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis [inference]

intracellular phosphate ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response [inference]

antibacterial innate immune response

response to water deprivation

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

multicellular organismal response to stress

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

innate immune response [inference]

antibacterial innate immune response

response to abiotic stimulus [inference]

response to water [inference]

response to water deprivation

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to water deprivation

response to xenobiotic stimulus

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to water [inference]

response to water deprivation

response to organonitrogen compound [inference]

ERAD pathway

response to lipid [inference]

response to lipopolysaccharide

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to inorganic substance [inference]

response to water [inference]

response to water deprivation

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to oxygen-containing compound [inference]

response to water [inference]

response to water deprivation

response to lipopolysaccharide

response to salt [inference]

response to water [inference]

response to water deprivation

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to cell periphery [inference]

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport [inference]

renal sodium ion absorption

secretion [inference]

acid secretion [inference]

citric acid secretion

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

transmembrane transport [inference]

urea transmembrane transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

organic anion transport [inference]

urate transport

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

one-carbon compound transport [inference]

urea transport [inference]

urea transmembrane transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

citrate transport [inference]

citric acid secretion

urate transport

amide transport [inference]

urea transport [inference]

urea transmembrane transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to cell periphery [inference]

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of protein transport

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
cell surface	IBA
membrane	IDA	2249987
basolateral plasma membrane	IDA	20798515 7028707
apical plasma membrane	IDA	18025791 20798515 7028707
apical plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

extrinsic component of membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	32045104 32616672
IgG binding	IDA	20798515

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgG binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K18274

Name

uromodulin

References

20798515

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060062	familial juvenile hyperuricemic nephropathy	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 10** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000083	Renal insufficiency
HP:0000092	Renal tubular atrophy
HP:0000112	Nephropathy
HP:0000123	Nephritis
HP:0001997	Gout
HP:0002149	Hyperuricemia
HP:0003621	Juvenile onset
HP:0003676	Progressive
HP:0012213	Decreased glomerular filtration rate