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collagen type XIV alpha 1 chain

Summary

Gene Symbol

COL14A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7373

PubChem

7373

Alliance of Genome Resources

HGNC:2191

Annotation

Keyword

Alternative splicing
Cell adhesion
Collagen
Direct protein sequencing
Disulfide bond
Extracellular matrix
Glycoprotein
Hydroxylation
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q05707	Undulin

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
ventricular cardiac muscle tissue development	IEA
extracellular matrix organization	NAS	9427527
collagen fibril organization	NAS	2187872
homeostasis of number of cells within a tissue	IEA
regulation of cell growth involved in cardiac muscle cell development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development [inference]

ventricular cardiac muscle tissue development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

homeostasis of number of cells within a tissue

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

homeostasis of number of cells within a tissue

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of developmental growth [inference]

regulation of organ growth [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of cellular process [inference]

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

regulation of cell growth involved in cardiac muscle cell development

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

regulation of cell growth involved in cardiac muscle cell development

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	HDA	27068509
collagen trimer	NAS	9427527
collagen type XIV trimer	NAS	9427527
interstitial matrix	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

collagen trimer

FACIT collagen trimer [inference]

collagen type XIV trimer

anchoring collagen complex [inference]

collagen type XIV trimer

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

interstitial matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674
extracellular matrix structural constituent	NAS	2187872 9427527
collagen binding	NAS	2187872
extracellular matrix structural constituent conferring tensile strength	RCA	20551380 25037231 28327460 28675934
extracellular matrix structural constituent conferring tensile strength	ISS

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

extracellular matrix structural constituent conferring tensile strength

binding [inference]

protein-containing complex binding [inference]

collagen binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen alpha-1 chain

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3748	esophagus squamous cell carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7373	Xenbase:XB-GENE-990916
Xenopus tropicalis	12818	Xenbase:XB-GENE-990916
Rattus norvegicus	314981		RATNO39433
Danio rerio	321298		DANRE10302
Pan troglodytes	464358		PANTR43184
Canis lupus familiaris	475085		CANLF03180
Macaca mulatta	702878		MACMU43332
Bos taurus	781493		BOVIN06270
Equus caballus	100033841		HORSE42591
Sus scrofa	100157658		PIGXX22948

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements