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oxoglutarate dehydrogenase

Summary

Gene Symbol

OGDH

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 738474
KEGG Gene ID: ptr:738474
PubChem: 738474

Annotation

Keyword

Calcium
Isopeptide bond
Nucleus
Oxidoreductase
Reference proteome
Thiamine pyrophosphate
Transit peptide
Ubl conjugation

Proteins

Displaying **all 8** entries
UniProt	Protein Name
A0A6D2WSL2	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
A0A6D2X686	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
A0A2I3S2G3	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
A0A6D2XF61	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
A0A2I3TTC8	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
A0A6D2WY86	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
K7CRV4	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
H2QUI7	2-oxoglutarate dehydrogenase, mitochondrial Alpha-ketoglutarate dehydrogenase Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
tricarboxylic acid cycle	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

tricarboxylic acid cycle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
oxoglutarate dehydrogenase complex	IEA	30032202
mitochondrion	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

dihydrolipoyl dehydrogenase complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

dihydrolipoyl dehydrogenase complex [inference]

oxoglutarate dehydrogenase complex

transferase complex [inference]

oxoglutarate dehydrogenase complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
oxoglutarate dehydrogenase (succinyl-transferring) activity	IEA	22301074 30032202
thiamine pyrophosphate binding	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [inference]

oxoglutarate dehydrogenase (succinyl-transferring) activity

binding [inference]

small molecule binding [inference]

vitamin binding [inference]

thiamine pyrophosphate binding

quaternary ammonium group binding [inference]

thiamine pyrophosphate binding

heterocyclic compound binding [inference]

thiamine pyrophosphate binding

ion binding [inference]

anion binding [inference]

thiamine pyrophosphate binding

cation binding [inference]

thiamine pyrophosphate binding

organic cyclic compound binding [inference]

thiamine pyrophosphate binding

sulfur compound binding [inference]

thiamine pyrophosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

2-oxoglutarate dehydrogenase E1 component

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying entries **1 - 10** of 18 in total

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Gene Ontology
2-oxoglutarate metabolic process
cerebellar cortex development
generation of precursor metabolites and energy
hippocampus development
histone succinylation
metal ion binding
olfactory bulb mitral cell layer development
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
oxidoreductase activity
oxoglutarate dehydrogenase (NAD+) activity

Displaying **all 7** entries
InterPro
2-oxoglutarate dehydrogenase E1 component, N-terminal domain
2-oxoglutarate dehydrogenase E1 component
Dehydrogenase, E1 component
Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily
Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
Thiamin diphosphate-binding fold
Transketolase-like, pyrimidine-binding domain

KEGG BRITE Database

Orthology

K00164

Name

2-oxoglutarate dehydrogenase E1 component [EC:1.2.4.2]

References

Rhea

RHEA:12188

H⁺ + 2-oxoglutarate

CO₂

Enzyme

1.2.4.2

PMID

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	4967	9606_0:0007bc	HUMAN88814
Mus musculus	18293		MOUSE06917
Rattus norvegicus	360975		RATNO08896
Bos taurus	534599		BOVIN28240
Danio rerio	564552		DANRE43165
Macaca mulatta	698854		MACMU32920
Danio rerio	797715		DANRE00348
Equus caballus	100065225		HORSE32205
Ornithorhynchus anatinus	100087515		ORNAN02645
Pongo abelii	100172216	9601_0:0021a2	PONAB32559

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements