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ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Summary

Gene Symbol

UQCRFS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7386

PubChem

7386

Alliance of Genome Resources

HGNC:12587

Annotation

Keyword

2Fe-2S
3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Mitochondrion inner membrane
Primary mitochondrial disease
Reference proteome
Respiratory chain
Transit peptide
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P47985	Complex III subunit 5 Cytochrome b-c1 complex subunit 5 Rieske iron-sulfur protein Rieske protein UQCRFS1 Ubiquinol-cytochrome c reductase iron-sulfur subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrial electron transport, ubiquinol to cytochrome c	IBA
mitochondrial respiratory chain complex III assembly	IMP	31883641
respiratory electron transport chain	IMP	31883641
proton transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial inner membrane	TAS
respiratory chain complex III	IBA IC IDA	23168492 31883641
mitochondrion	HDA HTP IDA	20833797 31883641 34800366
mitochondrial matrix
mitochondrial respiratory chain complex III

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

respiratory chain complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex III

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

oxidoreductase complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

mitochondrial respiratory chain complex III

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23168492 27499296 28380382 33961781
oxidoreductase activity	IBA
metal ion binding	IEA
2 iron, 2 sulfur cluster binding	IEA
ubiquinol-cytochrome-c reductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

electron transfer activity [inference]

ubiquinol-cytochrome-c reductase activity

oxidoreductase activity, acting on diphenols and related substances as donors [inference]

ubiquinol-cytochrome-c reductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

2 iron, 2 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome b-c1 complex subunit rieske

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
2 iron, 2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
mitochondrial electron transport, ubiquinol to cytochrome c
oxidoreductase activity

Displaying **all 7** entries
InterPro
Cytochrome b-c1 complex subunit Rieske, transmembrane domain
Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily
Rieske [2Fe-2S] iron-sulphur domain superfamily
Rieske [2Fe-2S] iron-sulphur domain
Rieske iron-sulphur protein, C-terminal
Rieske iron-sulphur protein
Ubiquinol-cytochrome c reductase, iron-sulphur subunit

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111139	mitochondrial complex III deficiency	Alliance of Genome Resources
DOID:700	mitochondrial metabolism disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	44390	FB:FBgn0021906
Mus musculus	66694	MGI:1913944	MOUSE10869
Caenorhabditis elegans	177609	WB:WBGene00002162
Bos taurus	287020		BOVIN10098
Rattus norvegicus	291103	RGD:628838	RATNO12313
Xenopus laevis	379942	Xenbase:XB-GENE-5746715
Xenopus tropicalis	394506	Xenbase:XB-GENE-5746219
Danio rerio	406359	ZFIN:ZDB-GENE-040426-2060	DANRE40102
Canis lupus familiaris	476503		CANLF01271
Macaca mulatta	700087		MACMU18786

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements