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ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

Summary

Gene Symbol

UQCRFS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7386

PubChem

7386

Alliance of Genome Resources

HGNC:12587

Annotation

Keyword

2Fe-2S
3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Mitochondrion inner membrane
Primary mitochondrial disease
Reference proteome
Respiratory chain
Transit peptide
Translocase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P47985	Complex III subunit 5 Cytochrome b-c1 complex subunit 5 Rieske iron-sulfur protein Rieske protein UQCRFS1 Ubiquinol-cytochrome c reductase iron-sulfur subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrial electron transport, ubiquinol to cytochrome c	IBA
respiratory electron transport chain	IMP	31883641
mitochondrial respiratory chain complex III assembly	IMP	31883641
proton transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

electron transport chain [inference]

respiratory electron transport chain

aerobic electron transport chain [inference]

mitochondrial electron transport, ubiquinol to cytochrome c

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex III assembly [inference]

mitochondrial respiratory chain complex III assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial respiratory chain complex III assembly

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

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GO Term	Evidence Code	PMID
mitochondrion	IDA	31883641
mitochondrion	HTP	34800366
mitochondrion	HDA	20833797
mitochondrial inner membrane	TAS
mitochondrial matrix	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

respiratory chain complex [inference]

respiratory chain complex III

transmembrane transporter complex [inference]

respiratory chain complex III

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex III

oxidoreductase complex [inference]

respiratory chain complex III

transporter complex [inference]

transmembrane transporter complex [inference]

respiratory chain complex III

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23168492 27499296 28380382 33961781
ubiquinol-cytochrome-c reductase activity	IEA
oxidoreductase activity	IBA
metal ion binding	IEA
2 iron, 2 sulfur cluster binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

electron transfer activity [inference]

ubiquinol-cytochrome-c reductase activity

oxidoreductase activity, acting on diphenols and related substances as donors [inference]

ubiquinol-cytochrome-c reductase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

active monoatomic ion transmembrane transporter activity [inference]

ubiquinol-cytochrome-c reductase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

2 iron, 2 sulfur cluster binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome b-c1 complex subunit Rieske

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
2 iron, 2 sulfur cluster binding
iron-sulfur cluster binding
metal ion binding
mitochondrial electron transport, ubiquinol to cytochrome c
oxidoreductase activity

Displaying **all 7** entries
InterPro
Cytochrome b-c1 complex subunit Rieske, transmembrane domain
Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily
Rieske [2Fe-2S] iron-sulphur domain superfamily
Rieske [2Fe-2S] iron-sulphur domain
Rieske iron-sulphur protein, C-terminal
Rieske iron-sulphur protein
Ubiquinol-cytochrome c reductase, iron-sulphur subunit

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111139	mitochondrial complex III deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7386	Xenbase:XB-GENE-5746219
Mus musculus	66694		MOUSE10869
Bos taurus	287020		BOVIN10098
Rattus norvegicus	291103	Xenbase:XB-GENE-5746219	RATNO12313
Danio rerio	406359		DANRE40102
Canis lupus familiaris	476503		CANLF01271
Macaca mulatta	700087		MACMU18786
Macaca mulatta	705178		MACMU18786
Pan troglodytes	741344		PANTR17831
Monodelphis domestica	100012527		MONDO05622

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Annotation

OrthoDB (Group)

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Acknowledgements