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uroporphyrinogen III synthase

Summary

Gene Symbol

UROS

Organism

Homo sapiens (human)

External Links

NCBI Gene

7390

PubChem

7390

Alliance of Genome Resources

HGNC:12592

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Heme biosynthesis
Lyase
Porphyrin biosynthesis
Proteomics identification
Reference proteome

Proteins

Displaying **all 6** entries
UniProt	Protein Name
P10746	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase
A0A3B3ITJ2	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase
A0A3B3ISM6	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase
A0A0S2Z5C5	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase
A0A0S2Z4T8	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase
Q5T3L8	Hydroxymethylbilane hydrolyase [cyclizing] Uroporphyrinogen-III cosynthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
uroporphyrinogen III biosynthetic process	IDA	18004775 3174619 3805019
uroporphyrinogen III biosynthetic process	IBA
protoporphyrinogen IX biosynthetic process	IEA
heme biosynthetic process	TAS
heme biosynthetic process	IC	18004775

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

uroporphyrinogen III biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

uroporphyrinogen III metabolic process [inference]

uroporphyrinogen III biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

heme biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

cellular response to amine stimulus

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

response to inorganic substance [inference]

response to metal ion [inference]

response to platinum ion

response to arsenic-containing substance [inference]

cellular response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

cellular response to amine stimulus

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to arsenic-containing substance

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amine stimulus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	ISS
cytosol	NAS	3805019
cytosol	TAS
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
uroporphyrinogen-III synthase activity	TAS
uroporphyrinogen-III synthase activity	IDA	18004775 3174619 3805019
uroporphyrinogen-III synthase activity	IBA
folic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

uroporphyrinogen-III synthase activity

binding [inference]

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uroporphyrinogen III synthase

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
porphyrin-containing compound biosynthetic process
protoporphyrinogen IX biosynthetic process
tetrapyrrole biosynthetic process
uroporphyrinogen III biosynthetic process
uroporphyrinogen-III synthase activity

Displaying **all 3** entries
InterPro
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase superfamily
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
Uroporphyrinogen-III synthase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13271	cutaneous porphyria	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7390	Xenbase:XB-GENE-999530
Mus musculus	22276		MOUSE55922
Rattus norvegicus	309070		RATNO20275
Danio rerio	404731		DANRE04788
Pan troglodytes	450813		PANTR01777
Canis lupus familiaris	492116		CANLF11572
Bos taurus	613425		BOVIN21732
Macaca mulatta	696043		MACMU45677
Monodelphis domestica	100010046		MONDO07361
Equus caballus	100056401		HORSE15553

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Acknowledgements