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N-acylethanolamine acid amidase

Summary

Gene Symbol

NAAA

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 739402
KEGG Gene ID: ptr:739402
PubChem: 739402

Annotation

Keyword

Autocatalytic cleavage
Fatty acid metabolism
Glycoprotein
Hydrolase
Lipid degradation
Lysosome
Membrane
Reference proteome
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
H2QPQ0	Acylsphingosine deacylase NAAA
A0A6D2Y846	Acylsphingosine deacylase NAAA
A0A6D2XTB9	Acylsphingosine deacylase NAAA
A0A2I3TP10	Acylsphingosine deacylase NAAA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
N-acylethanolamine metabolic process
fatty acid metabolic process	IEA	22301074
N-acylphosphatidylethanolamine metabolic process
lipid catabolic process
sphingosine metabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

organic substance catabolic process [inference]

lipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane
lysosome	IEA	22301074

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
DNA-binding transcription factor binding
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
ceramidase activity
fatty acid amide hydrolase activity	IEA	22301074
N-acylsphingosine amidohydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

binding [inference]

protein binding [inference]

transcription factor binding [inference]

DNA-binding transcription factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

N-acylethanolamine-hydrolyzing acid amidase isoform X1

Functional Category

M: Cell wall/membrane/envelope biogenesis

Displaying **all 10** entries
Gene Ontology
N-(long-chain-acyl)ethanolamine deacylase activity
N-acylethanolamine metabolic process
N-acylphosphatidylethanolamine metabolic process
N-acylsphingosine amidohydrolase activity
ceramidase activity
fatty acid metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity
lipid metabolic process
sphingosine metabolic process

Displaying **all 3** entries
InterPro
Acid ceramidase, N-terminal
Acid ceramidase-like
Choloylglycine hydrolase/NAAA C-terminal

KEGG BRITE Database

Orthology

K13720

Name

N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]

References

15655246

Rhea

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

RHEA:17505

H₂O + N-(long-chain fatty acyl)ethanolamine

a long-chain fatty acid + ethanolamine

Enzyme

3.5.1.60

PMID

4055775

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	27163	9606_1:001314	HUMAN76016
Mus musculus	67111		MOUSE45714
Rattus norvegicus	497009		RATNO08847
Macaca mulatta	700991		MACMU37716
Monodelphis domestica	100024438		MONDO25974
Equus caballus	100057831		HORSE31304
Ciona intestinalis	100185070		CIOIN01042
Taeniopygia guttata	100223326		TAEGU23744
Callithrix jacchus	100399529		CALJA28079
Pongo abelii	100450814	9601_0:001530	PONAB28010