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solute carrier family 25, member 27

Summary

Gene Symbol

Slc25a27

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74011

PubChem

74011

Alliance of Genome Resources

MGI:1921261

Annotation

Keyword

Cell projection
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D6D0	Solute carrier family 25, member 27

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	ISO
response to cold	IBA
negative regulation of mitochondrial membrane potential	ISO
intracellular triglyceride homeostasis	ISO
negative regulation of apoptotic process	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

proton transmembrane transport

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular triglyceride homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

intracellular triglyceride homeostasis

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis [inference]

intracellular triglyceride homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

mitochondrial calcium ion homeostasis [inference]

negative regulation of mitochondrial calcium ion concentration

response to stimulus [inference]

response to stress [inference]

response to cold

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

proton transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

regulation of glucose import

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of neuron apoptotic process

regulation of biological quality [inference]

regulation of membrane potential [inference]

negative regulation of membrane potential [inference]

negative regulation of mitochondrial membrane potential

regulation of mitochondrial membrane potential [inference]

negative regulation of mitochondrial membrane potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IDA	19646951
mitochondrion	HDA	14651853 18614015
mitochondrial inner membrane	IDA	25237189
neuron projection	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

cell body [inference]

neuronal cell body

apical part of cell

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
proton transmembrane transporter activity	ISO
proton transmembrane transporter activity	IEA
chloride transmembrane transporter activity	ISO
chloride transmembrane transporter activity	IEA
transmembrane transporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mitochondrial uncoupling protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
response to cold

Displaying **all 2** entries
InterPro
Mitochondrial carrier domain superfamily
Mitochondrial substrate/solute carrier

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9481		HUMAN85092
Xenopus tropicalis	74011	Xenbase:XB-GENE-1005902
Rattus norvegicus	85262		RATNO42500
Danio rerio	393312		DANRE20047
Pan troglodytes	472019		PANTR38308
Bos taurus	536813		BOVIN18605
Canis lupus familiaris	609887		CANLF02814
Macaca mulatta	704343		MACMU33995
Monodelphis domestica	100014438		MONDO14723
Equus caballus	100055797		HORSE19489