GlyCosmos Portal

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GO Term	Evidence Code	PMID
RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
protein binding	IPI	17178841 24981860 27705803 32296183 33961781 34667079
chromatin DNA binding	IBA
histone demethylase activity	TAS
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

histone modifying activity [inference]

histone demethylase activity

histone H3 demethylase activity [inference]

histone H3K27me2/H3K27me3 demethylase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

chromatin binding [inference]

chromatin DNA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

chromatin DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

RNA polymerase II transcription regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

cis-regulatory region sequence-specific DNA binding [inference]

RNA polymerase II cis-regulatory region sequence-specific DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysine-specific demethylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chromatin DNA binding
histone H3K27me2/H3K27me3 demethylase activity
histone demethylase activity
metal ion binding
oxidoreductase activity
regulation of gene expression

Displaying **all 5** entries
InterPro
JmjC domain
Lysine-specific demethylase 6, GATA-like domain superfamily
Lysine-specific demethylase 6A/B-like, C-terminal helical domain
Lysine-specific demethylase 6A/B-like, GATA-like
Tetratricopeptide repeat

Disease

Disease Ontology

Displaying entries **11 - 12** of 12 in total

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DO ID	Disease Name	Source
DOID:9256	colorectal cancer	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **91 - 93** of 93 in total

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Species	Gene ID	Orthologous MAtrix
Rhinolophus ferrumequinum	117022216	RHIFE17602
Scophthalmus maximus	118282826	SCOMX07492
Balaenoptera musculus	118888822	BALMU19109

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements