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lon peptidase 1, mitochondrial

Summary

Gene Symbol

Lonp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74142

PubChem

74142

Alliance of Genome Resources

MGI:1921392

Annotation

Keyword

ATP-binding
DNA-binding
Direct protein sequencing
Mitochondrion
Reference proteome
Serine protease
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CGK3	Lon protease-like protein Mitochondrial ATP-dependent protease Lon Serine protease 15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	12657466
protein-containing complex assembly	ISO
negative regulation of insulin receptor signaling pathway	IDA	9813005
regulation of peptidyl-tyrosine phosphorylation	IDA	9813005
response to hypoxia	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

protein quality control for misfolded or incompletely synthesized proteins

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

oxidation-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cellular component assembly [inference]

protein-containing complex assembly

chaperone-mediated protein complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

chaperone-mediated protein complex assembly

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

cellular response to oxidative stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

regulation of peptidyl-tyrosine phosphorylation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IEA ISO
mitochondrion	HDA IDA ISO	12657466 14651853 18614015
mitochondrial matrix	IBA ISO
mitochondrial nucleoid	IEA ISO
cytosol	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
insulin receptor substrate binding	IPI	9813005
G-quadruplex DNA binding	IEA ISO
single-stranded RNA binding	IEA ISO
ATP hydrolysis activity	IDA	12657466
single-stranded DNA binding	IBA IDA	12657466

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

ATP-dependent peptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

ATP-dependent peptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

DNA polymerase binding

protein domain specific binding [inference]

PH domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

single-stranded DNA binding

sequence-specific DNA binding

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

G-quadruplex DNA binding

RNA binding [inference]

single-stranded RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP-dependent activity [inference]

ATP-dependent peptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Lon protease

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
ATP binding
cellular response to oxidative stress
hydrolase activity
mitochondrion organization
nucleotide binding
oxidation-dependent protein catabolic process
protein quality control for misfolded or incompletely synthesized proteins
proteolysis
sequence-specific DNA binding
serine-type endopeptidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
AAA+ ATPase domain
ATPase, AAA-type, core
Lon protease homologue, chloroplastic/mitochondrial
Lon protease, N-terminal domain superfamily
Lon protease, N-terminal domain
Lon protease, bacterial/eukaryotic-type
Lon protease
P-loop containing nucleoside triphosphate hydrolase
PUA-like superfamily
Peptidase S16, Lon proteolytic domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111274	CODAS syndrome	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:326	ischemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **127** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9361		HGNC:9479	HUMAN40008
Drosophila melanogaster	40138		FB:FBgn0036892
Rattus norvegicus	170916	10116_1:003124	RGD:621598	RATNO42709
Caenorhabditis elegans	172966		WB:WBGene00016391
Pan troglodytes	455623			PANTR16881
Bos taurus	510796			BOVIN32839
Danio rerio	563257		ZFIN:ZDB-GENE-030131-4006	DANRE22761
Macaca mulatta	700284			MACMU20559
Saccharomyces cerevisiae S288C	852259		SGD:S000000118
Monodelphis domestica	100024990			MONDO19307

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements