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voltage dependent anion channel 2

Summary

Gene Symbol

VDAC2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7417

PubChem

7417

Alliance of Genome Resources

HGNC:12672

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Direct protein sequencing
Isopeptide bond
Lipid transport
Lipid-binding
Mitochondrion outer membrane
NAD
Nucleotide-binding
Phosphoprotein
Porin
Reference proteome
Transmembrane beta strand
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P45880	Outer mitochondrial membrane protein porin 2
A0A024QZT0	Outer mitochondrial membrane protein porin 2
B4DKM5	Outer mitochondrial membrane protein porin 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
anion transport	IDA	8420959
monoatomic anion transport	IDA	8420959
binding of sperm to zona pellucida	IMP	23355646
plasma membrane phospholipid scrambling	IEA
negative regulation of protein polymerization	IEA

GO Hierarchy

biological process

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

mitochondrial transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

apoptotic mitochondrial changes [inference]

regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

membrane organization [inference]

mitochondrial membrane organization [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

plasma membrane organization [inference]

plasma membrane phospholipid scrambling

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

plasma membrane phospholipid scrambling

reproductive process [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

mitochondrial transport [inference]

mitochondrial transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

mitochondrial transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport [inference]

phospholipid translocation

plasma membrane phospholipid scrambling

lipid translocation [inference]

phospholipid translocation

plasma membrane phospholipid scrambling

organophosphate ester transport [inference]

phospholipid transport [inference]

phospholipid translocation

plasma membrane phospholipid scrambling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization

regulation of protein polymerization [inference]

negative regulation of protein polymerization

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization

regulation of protein polymerization [inference]

negative regulation of protein polymerization

negative regulation of cellular component organization [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization

regulation of biological quality [inference]

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

positive regulation of membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

mitochondrial outer membrane permeabilization involved in programmed cell death [inference]

positive regulation of mitochondrial membrane permeability involved in apoptotic process [inference]

mitochondrial outer membrane permeabilization

regulation of membrane lipid distribution [inference]

lipid translocation [inference]

phospholipid translocation

plasma membrane phospholipid scrambling

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IDA	23355646
nucleus	HDA	21630459
mitochondrion	IDA
mitochondrion	HTP	34800366
mitochondrion	HDA	20833797

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex

cellular anatomical entity [inference]

nucleoid [inference]

mitochondrial nucleoid

membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

membrane microdomain [inference]

membrane raft

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular non-membrane-bounded organelle [inference]

mitochondrial nucleoid

sperm midpiece

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
voltage-gated monoatomic ion channel activity	IDA	8420959
protein binding	IPI	15082785 17500595 23355646 26618866 29128334 30021884 32814053 35156780 35271311 36012204
ATP binding	IEA
oxysterol binding	ISS
voltage-gated monoatomic anion channel activity	IDA	38065946

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phospholipid scramblase activity

intramembrane lipid transporter activity [inference]

phospholipid scramblase activity

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

wide pore channel activity [inference]

porin activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

sphingolipid binding [inference]

ceramide binding

amide binding [inference]

ceramide binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

phosphatidylcholine binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Voltage-dependent anion-selective channel

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
porin activity

Displaying **all 3** entries
InterPro
Eukaryotic porin/Tom40
Porin domain superfamily
Porin, eukaryotic type

Ortholog

Displaying entries **1 - 10** of **113** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	7416	SGD:S000005000
Xenopus tropicalis	7417	Xenbase:XB-GENE-954839
Saccharomyces cerevisiae S288C	7419	SGD:S000005000
Saccharomyces cerevisiae S288C	22333	SGD:S000005000
Mus musculus	22334	Xenbase:XB-GENE-954839	MOUSE14034
Saccharomyces cerevisiae S288C	22335	SGD:S000005000
Saccharomyces cerevisiae S288C	83529	SGD:S000005000
Rattus norvegicus	83531	Xenbase:XB-GENE-954839	RATNO09895
Bos taurus	282120		BOVIN22592
Danio rerio	322126		DANRE05057

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OrthoDB (Group)

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Acknowledgements