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voltage dependent anion channel 3

Summary

Gene Symbol

VDAC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7419

PubChem

7419

Alliance of Genome Resources

HGNC:12674

Annotation

Keyword

Acetylation
Alternative splicing
Isopeptide bond
Mitochondrion outer membrane
NAD
Nucleotide-binding
Phosphoprotein
Porin
Reference proteome
Transmembrane beta strand
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y277	Outer mitochondrial membrane protein porin 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
behavioral fear response	IEA
sperm mitochondrial sheath assembly	ISS
adenine transport	TAS	9781040
learning	IEA
spermatogenesis	ISS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

cellular process involved in reproduction in multicellular organism [inference]

sperm mitochondrial sheath assembly

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

sperm mitochondrial sheath assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

sperm mitochondrial sheath assembly

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

organic substance transport [inference]

nucleobase transport [inference]

purine nucleobase transport [inference]

adenine transport

nitrogen compound transport [inference]

nucleobase transport [inference]

purine nucleobase transport [inference]

adenine transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IDA	27641616
pore complex	IEA
mitochondrial outer membrane	IBA TAS
mitochondrion	HDA HTP IDA	20833797 34800366
nucleus	HDA	21630459

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex

cellular anatomical entity [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	29128334 30021884 35271311
voltage-gated monoatomic anion channel activity	IBA TAS	9781040
porin activity	IEA
nucleotide binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

wide pore channel activity [inference]

porin activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic anion channel activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent anion-selective channel

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
porin activity

Displaying **all 3** entries
InterPro
Eukaryotic porin/Tom40
Porin domain superfamily
Porin, eukaryotic type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:8466	retinal degeneration	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 98 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22335		MGI:106922	MOUSE58522
Drosophila melanogaster	34500		FB:FBgn0004363
Rattus norvegicus	83532		RGD:621577	RATNO10678
Caenorhabditis elegans	177524		WB:WBGene00019900
Bos taurus	282716			BOVIN22168
Danio rerio	393186		ZFIN:ZDB-GENE-040426-954
Sus scrofa	397651			PIGXX11167
Danio rerio	406529		ZFIN:ZDB-GENE-040426-2380	DANRE43318
Xenopus laevis	443782		Xenbase:XB-GENE-949893
Xenopus tropicalis	496695		Xenbase:XB-GENE-949888

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024