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MIRAGE
vascular endothelial growth factor A
Summary
- Gene Symbol
-
- VEGFA
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative initiation
- Alternative promoter usage
- Alternative splicing
- Angiogenesis
- Cytoplasm
- Developmental protein
- Differentiation
- Direct protein sequencing
- Disulfide bond
- Endoplasmic reticulum
- Extracellular matrix
- Glycoprotein
- Golgi apparatus
- Growth factor
- Heparin-binding
- Mitogen
- Nucleus
- Proteomics identification
- Reference proteome
- Secreted
- Signal
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0Y0IMM4 |
|
| P15692 |
|
| A2A2V4 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| angiogenesis | ||
| ovarian follicle development | ||
| branching involved in blood vessel morphogenesis | ||
| vasculogenesis |
GO Hierarchy
- positive regulation of cell division
- positive regulation of cell division
biological process
cellular process [inference]
signal transduction [inference]
multicellular organismal process [inference]
developmental process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
regulation of growth [inference]
regulation of locomotion [inference]
positive regulation of locomotion [inference]
regulation of cell motility [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of locomotion [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell motility [inference]
positive regulation of response to stimulus [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of cell population proliferation [inference]
regulation of cellular component biogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cell motility [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cell motility [inference]
regulation of multicellular organismal process [inference]
regulation of epithelial cell migration [inference]
positive regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| extracellular space | ||
| extracellular space | ||
| nucleus |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| fibronectin binding | ||
| cytokine activity | ||
| cytokine activity | ||
| platelet-derived growth factor receptor binding | ||
| vascular endothelial growth factor receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Vascular endothelial growth factor
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| InterPro |
|---|
| Cystine-knot cytokine |
| PDGF/VEGF domain |
| Platelet-derived growth factor, conserved site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111252 | vestibular schwannomatosis | |
| DOID:10283 | prostate cancer | |
| DOID:10591 | pre-eclampsia | |
| DOID:10652 | Alzheimer's disease | |
| DOID:10763 | hypertension | |
| DOID:10873 | Kuhnt-Junius degeneration | |
| DOID:11713 | diabetic angiopathy | |
| DOID:12361 | Graves' disease | |
| DOID:12689 | acoustic neuroma | |
| DOID:13378 | Kawasaki disease |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 7422 | Xenbase:XB-GENE-485744 | ||
| 22339 | Xenbase:XB-GENE-485744 | ||
| 30682 | Xenbase:XB-GENE-485744 | ||
| 83785 | Xenbase:XB-GENE-485744 | RATNO42403 | |
| 281572 | BOVIN18562 | ||
| 493845 | FELCA12631 | ||
| 574209 | MACMU34310 | ||
| 100713483 | CAVPO08580 | ||
| 100860957 | CAPHI15644 | ||
| 101951073 | CHRPI34010 |
