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vasoactive intestinal peptide receptor 1

Summary

Gene Symbol

VIPR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7433

PubChem

7433

Alliance of Genome Resources

HGNC:12694

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P32241	Pituitary adenylate cyclase-activating polypeptide type II receptor VPAC1
B4DNY6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway	TAS	8179610
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA	8390245
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	36385145

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	8179610
plasma membrane	IBA
receptor complex	IDA	23382219

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
pituitary adenylate cyclase-activating polypeptide receptor activity	IDA	36385145
vasoactive intestinal polypeptide receptor activity	IDA	36385145 8390245
vasoactive intestinal polypeptide receptor activity	IBA
protein binding	IPI	23597562 32296183
G protein-coupled peptide receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vasoactive intestinal polypeptide

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding

Displaying **all 5** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9164	achalasia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of **102** in total

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Species	Gene ID	Orthologous MAtrix
Macaca mulatta	717438	MACMU29236
Oryctolagus cuniculus	100009518	RABIT12598
Monodelphis domestica	100026994	MONDO30042
Sus scrofa	100155402	PIGXX03834
Taeniopygia guttata	100226500	TAEGU18741
Danio rerio	100334247	DANRE29206
Callithrix jacchus	100396852	CALJA14969
Pongo abelii	100437846	PONAB25062
Nomascus leucogenys	100603830	NOMLE28091
Loxodonta africana	100667017	LOXAF14866

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements