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vasoactive intestinal peptide receptor 2

Summary

Gene Symbol

VIPR2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7434

PubChem

7434

Alliance of Genome Resources

HGNC:12695

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
X5D7Q6
P41587	Helodermin-preferring VIP receptor Pituitary adenylate cyclase-activating polypeptide type III receptor VPAC2
X5DP12

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
signal transduction	TAS	7811244
cell surface receptor signaling pathway	IEA
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	35477937 8933357
adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	35477937

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of smooth muscle cell proliferation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	35477937
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

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GO Term	Evidence Code	PMID
pituitary adenylate cyclase-activating polypeptide receptor activity	IMP	35477937
G protein-coupled receptor activity	TAS	7811244
vasoactive intestinal polypeptide receptor activity	IDA	8933357
vasoactive intestinal polypeptide receptor activity	IBA
G protein-coupled peptide receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

amide binding [inference]

peptide binding [inference]

peptide hormone binding

hormone binding [inference]

peptide hormone binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vasoactive intestinal polypeptide

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
G protein-coupled peptide receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
cell surface receptor signaling pathway
peptide hormone binding

Displaying **all 5** entries
InterPro
GPCR family 2, extracellular hormone receptor domain superfamily
GPCR, family 2, extracellular hormone receptor domain
GPCR, family 2, secretin-like, conserved site
GPCR, family 2, secretin-like
GPCR, family 2-like, 7TM

Ortholog

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	117	FB:FBgn0260753
Drosophila melanogaster	2692	FB:FBgn0260753
Drosophila melanogaster	2696	FB:FBgn0260753
Drosophila melanogaster	2740	FB:FBgn0260753
Drosophila melanogaster	7433	FB:FBgn0260753
Xenopus tropicalis	7434	Xenbase:XB-GENE-966330
Drosophila melanogaster	11517	FB:FBgn0260753
Drosophila melanogaster	14602	FB:FBgn0260753
Drosophila melanogaster	14652	FB:FBgn0260753
Drosophila melanogaster	22354	FB:FBgn0260753